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Titolo:
The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?
Autore:
Olivier, B; Leahy, C; Mullen, T; Paylor, R; Groppi, VE; Sarnyai, Z; Brunner, D;
Indirizzi:
PsychoGen Inc, Hawthorne, NY 10532 USA PsychoGen Inc Hawthorne NY USA 10532 ychoGen Inc, Hawthorne, NY 10532 USA Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Pharmacia Corp, CNS Discovery Res, Kalamazoo, MI 49017 USA Pharmacia CorpKalamazoo MI USA 49017 covery Res, Kalamazoo, MI 49017 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 , Dept Psychiat, New Haven, CT 06508 USA Univ Utrecht, Fac Pharm, Dept Psychopharmacol, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 crinol Lab, New York, NY 10021 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 284 - 290
Fonte:
ISI
Lingua:
ENG
Soggetto:
INBRED MOUSE STRAINS; ALPHA-7 NICOTINIC RECEPTOR; ANIMAL-MODEL; ACOUSTIC STARTLE; SCHIZOPHRENIA; MICE; DEFICIENT; AGONISTS; RATS;
Keywords:
startle; prepulse inhibition; DBA/2J; antipsychotic; clozapine; risperidone; alpha(7) nicotinic receptor; GTS-21; AR-R17779; mouse strain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Olivier, B PsychoGen Inc, 4 Skyline Dr, Hawthorne, NY 10532 USA PsychoGen Inc 4 Skyline Dr Hawthorne NY USA 10532 NY 10532 USA
Citazione:
B. Olivier et al., "The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?", PSYCHOPHAR, 156(2-3), 2001, pp. 284-290

Abstract

Rationale: Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. Objectives: Establishment of amouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low performance PPI. Methods: Three strains of mice - C57B1/6J, 129S6/SvEvTac and DBA/2J - were tested in a startle paradigm with three prepulse intensities, 2, 4 and 8 dB above background. Results: Under these conditions, risperidone (0, 0.25, 0.5 and 1 mg/kg i.p.) and clozapine (0, 1, 3 and 9 mg/kg i.p.) improved PPI in all three strains, with order of effect in DBA/2J > 129S6SvEvTac > C57B1/6J. The DBA/2J strain showed larger PPI-enhancing effects, without disturbing the basal startle response. Two alpha (7) nicotinic receptor agonists, GTS-21 (1-10 mg/kg i.p.) and AR-R17779 (1-10 mg/kg i.p.) were inactive in the PPI procedure in DBA/2J mice. Conclusions: DBA/2J mice were very sensitive to the psychotic-like effects of atypical (clozapine) and typical (risperidone) antipsychotics, and this strain is proposed as a model to directly measure sensory gating properties of drugs. alpha (7) Nicotinergic receptor agonists were ineffective in this PPI paradigm.

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Documento generato il 23/01/20 alle ore 13:03:45