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Titolo:
Drug-induced potentiation of prepulse inhibition of acoustic startle reflex in mice: a model for detecting antipsychotic activity?
Autore:
Ouagazzal, AM; Jenck, F; Moreau, JL;
Indirizzi:
F Hoffmann La Roche & Co Ltd, Preclin CNS Res, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 273 - 283
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; PREFRONTAL CORTEX; INDUCED CATALEPSY; INBRED STRAINS; MOUSE STRAINS; ANIMAL-MODEL; RATS; ANXIETY; BENZODIAZEPINES; HABITUATION;
Keywords:
schizophrenia; prepulse inhibition; startle habituation; antipsychotic; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ouagazzal, AM Inst Genet & Biol Mol & Cellulaire, BP 163, F-67404 IllkirchGraffenstaden, France Inst Genet & Biol Mol & Cellulaire BP 163 Illkirch Graffenstaden France F-67404
Citazione:
A.M. Ouagazzal et al., "Drug-induced potentiation of prepulse inhibition of acoustic startle reflex in mice: a model for detecting antipsychotic activity?", PSYCHOPHAR, 156(2-3), 2001, pp. 273-283

Abstract

Rationale: Schizophrenic patients typically have impaired startle habituation (SH) and prepulse inhibition of the startle reflex (PPI). PPI can be disrupted in rats by psychomimetics, and drug-induced reversal of this deficit is considered to predict potential antipsychotic properties. Certain strains of mice, such as C57BL/6J, naturally display poor PPI. Objective: To test whether mice spontaneously showing low levels of PPI might prove a useful tool for detecting novel antipsychotics. Methods: PPI and SH were evaluated in four strains of mice: BALB/cByJ, MORO, 129/SvEv and C57BL/6J. The effects of antipsychotic [haloperidol (1, 3 and 6 mg/kg), clozapine (0.3, 1, 3and 30 mg/kg) and risperidone (0.1, 0.3 and 1 mg/kg,)] and non-antipsychotic [diazepam (3, 10 and 30 mg/kg), buspirone (1, 3 and 10 mg/kg), desipramine (3, 10 and 30 mg/kg), morphine (3, 10 and 30 mg/kg) and scopolamine (0.3, 1 and 3 mg/kg)] drug treatments were studied on PPI. Results: Haloperidol(6 mg/kg), clozapine (3 and 30 mg/kg), and risperidone (1 mg/kg) all significantly enhanced PPI in C57BL/6J. All non-antipsychotics failed to improvePPI in this strain, except diazepam. Facilitation of PPI was also obtainedin the other strains; however, clear interstrain differences were observeddepending on the class of antipsychotic used and on the level of prepulse intensity. Conclusion: Anti psychotic-induced facilitation of PPI is clearly detected in mice naturally exhibiting poor levels of sensorimotor gating (e.g., C57BL/6J), but is also observed in other strains of mice. The use ofthis procedure as a potential screening test for detecting novel antipsychotic medications is discussed.

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Documento generato il 25/01/20 alle ore 16:20:34