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Titolo:
Effects of smoking on acoustic startle and prepulse inhibition in humans
Autore:
Duncan, E; Madonick, S; Chakravorty, S; Parwani, A; Szilagyi, S; Efferen, T; Gonzenbach, S; Angrist, B; Rotrosen, J;
Indirizzi:
New York Harbor Vet Affairs Med Ctr, Psychiat Serv, New York, NY 10010 USANew York Harbor Vet Affairs Med Ctr New York NY USA 10010 k, NY 10010 USA NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA NYU New York NY USA 10016 Sch Med, Dept Psychiat, New York, NY 10016 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Med Ctr, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Med Ctr, Pittsburgh, PA 15213 USA Univ Maryland, Maryland Psychiat Res Ctr, Catonsville, MD 21228 USA Univ Maryland Catonsville MD USA 21228 Res Ctr, Catonsville, MD 21228 USA Atlanta VA Med Ctr, Mental Hlth Serv 116A, Decatur, GA 30033 USA Atlanta VA Med Ctr Decatur GA USA 30033 Serv 116A, Decatur, GA 30033 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 266 - 272
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEAK PRE-STIMULATION; CIGARETTE-SMOKING; ATTENTIONAL MODULATION; SCHIZOPHRENIC-PATIENTS; REFLEX; NICOTINE; RATS; NORMALIZATION; DEPENDENCE; PSYCHOSIS;
Keywords:
prepulse inhibition; sensorimotor gating; nicotine; smoking; acoustic startle reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, E New York Harbor Vet Affairs Med Ctr, Psychiat Serv, 423 E 23 St,New York,NY 10010 USA New York Harbor Vet Affairs Med Ctr 423 E 23 St New York NY USA 10010
Citazione:
E. Duncan et al., "Effects of smoking on acoustic startle and prepulse inhibition in humans", PSYCHOPHAR, 156(2-3), 2001, pp. 266-272

Abstract

Rationale: Prepulse inhibition of the acoustic startle response (PPI) is aparadigm in which a startle response to an auditory stimulus is reduced when that stimulus is preceded by a lower intensity, non-startling stimulus (prepulse). PPI is used as an operational measure of sensorimotor gating in both humans and other mammals. Acute administration of nicotine enhances PPI in rats, an effect that has been recently demonstrated in humans. Objectives: We compared PPI in 12 male smokers and 14 male non-smokers tested in four repeat startle sessions across 2 test days in order to examine further the effects of smoking and smoking withdrawal on acoustic startle and PPI. Methods: In a crossover design, the smokers smoked ad lib or abstained fromsmoking overnight prior to 9 a.m. testing. These 2 test days were in randomized order. On both days, smokers were immediately retested after smoking three cigarettes. Non-smokers were tested twice on each of 2 separate days. Results: Across sessions, the smokers had reduced startle to pulse alone stimuli in the first block of each session when compared to the non-smokers. The nonsmokers had no change in gating across their four test sessions. For the smokers, the abstinence condition produced a non-significant reduction in PPI compared to that of the ad lib smoking day. During the smoking abstinence session, smokers had comparable gating to nonsmokers. Smoking immediately after washout produced a significant improvement in PPI such that gating in the smokers exceeded that of the non-smokers. Conclusion: Smoking after overnight washout from cigarettes enhanced sensorimotor gating compared to pre-smoking values and compared to gating in non-smokers.

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Documento generato il 25/01/20 alle ore 19:23:23