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Titolo:
Brain stem circuits mediating prepulse inhibition of the startle reflex
Autore:
Fendt, M; Li, LA; Yeomans, JS;
Indirizzi:
Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany Beijing Univ, Dept Psychol, Beijing 100871, Peoples R China Beijing Univ Beijing Peoples R China 100871 jing 100871, Peoples R China Univ Toronto, Dept Psychol, Toronto, ON M5S 3G3, Canada Univ Toronto Toronto ON Canada M5S 3G3 ychol, Toronto, ON M5S 3G3, Canada
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 216 - 224
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PONTINE RETICULAR-FORMATION; RATS INFERIOR COLLICULUS; ACOUSTIC STARTLE; SUPERIOR COLLICULUS; ELECTRICAL-STIMULATION; CHOLINERGIC MODULATION; ATTENTIONAL PROCESSES; EYEBLINK MODIFICATION; BINAURAL RESPONSES;
Keywords:
acetylcholine; attention; caudal pontine reticular nucleus; GABA; inferior colliculus; laterodorsal tegmental nucleus; prepulse inhibition; peduculopontine tegmental nucleus; sensorimotor gating; startle response; substantia nigra pars reticulata; superior colliculus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Fendt, M Univ Tubingen, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 28 Tubingen Germany D-72076 , Germany
Citazione:
M. Fendt et al., "Brain stem circuits mediating prepulse inhibition of the startle reflex", PSYCHOPHAR, 156(2-3), 2001, pp. 216-224

Abstract

Rationale: Prepulse inhibition (PPI) of the startle reflex occurs when brief. non-startling tactile, acoustic or visual stimuli are presented 20-500 ms before the startling stimulus. Objective: To review information about PPI-mediating brain stem circuits and transmitters, and their functions. Results: Midbrain systems are most critical for the fast relay of these PPI stimuli. Acoustic prepulses for PPI are relayed through the inferior colliculus (IC). The superior colliculus (SC) is important for acoustic PPI, and maybe important for the mediation of tactile and visual prepulses. This collicular activation for PPI is quickly relayed through the pedunculopontine tegmental nucleus (PPTg), with lesser contributions to PPI from the laterodorsal tegmental nucleus (LDTg) and substantia nigra, pars reticulata (SNR). The transient activation of midbrain nuclei by PPI stimuli is converted intolong-lasting inhibition of the giant neurons of the caudal pontine reticular nucleus (PnC). We propose that muscarinic and GABAB inhibitory receptors(both metabotropic receptors) on PnC giant neurons combine to produce the long-lasting inhibition of startle. Activation of mesopontine cholinergic neurons leads to cortical arousal, turning and exploratory approach responses. Conclusion: PPI is mediated by a circuit involving the IC, SC, PPTg, LDTg, SNR and NC. By reducing startle, PPI allows the execution of approach responses and perceptual processing following salient stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:08:46