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Titolo:
The adenosine A(2A) agonist CGS 21680 reverses the reduction in prepulse inhibition of the acoustic startle response induced by phencyclidine, but not by apomorphine and amphetamine
Autore:
Sills, TL; Azampanah, A; Fletcher, PJ;
Indirizzi:
Clarke Inst Psychiat, Ctr Addict & Mental Hlth, Biopsychol Sect, Clarke Div, Toronto, ON M5T 1R8, Canada Clarke Inst Psychiat Toronto ON Canada M5T 1R8 oronto, ON M5T 1R8, Canada
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 187 - 193
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; RECEPTOR AGONISTS; ANIMAL-MODEL; DOPAMINE; SCHIZOPHRENIA; RATS; A(1); HABITUATION; STIMULATION; HALOPERIDOL;
Keywords:
acoustic startle response; NMDA receptor antagonist; locomotion; Wistar rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sills, TL Clarke Inst Psychiat, Ctr Addict & Mental Hlth, Biopsychol Sect,Clarke Div, 250 Coll St, Toronto, ON M5T 1R8, Canada Clarke Inst Psychiat 250 Coll St Toronto ON Canada M5T 1R8 anada
Citazione:
T.L. Sills et al., "The adenosine A(2A) agonist CGS 21680 reverses the reduction in prepulse inhibition of the acoustic startle response induced by phencyclidine, but not by apomorphine and amphetamine", PSYCHOPHAR, 156(2-3), 2001, pp. 187-193

Abstract

Systemic administration of the selective adenosine AZA agonist CGS 21680, at the highest dose tested (0.5 mg/kg), selectively reversed the reduction in prepulse inhibition (PPI) of the acoustic startle response induced by the NMDA antagonist phencyclidine (PCP), but not by the dopaminergic agonistsapomorphine and amphetamine. CGS 21680 by itself was without effect on PPI, but did reduce the amplitude of the startle response. PCP also reduced startle amplitude, but there was no additive or synergistic effect between PCP and CGS 21680 on the startle response. CGS 21680 (0.5 mg/kg) blocked the locomotor activating effect of amphetamine, but this may have been secondary to a reduction in spontaneous locomotion induced by this compound. Taken together, these results indicate that stimulation of adenosine A,A receptors produce no consequence on dopamine agonist-induced disruption in PPI, butregulate the inhibitory effect of NMDA receptor blockade on PPI. This finding raises the possibility that adenosine A,A agonists possess antipsychotic-like properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:32:18