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Titolo:
Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine
Autore:
Schulz, B; Fendt, M; Pedersen, V; Koch, M;
Indirizzi:
Univ Bremen, Inst Hirnforsch, D-28334 Bremen, Germany Univ Bremen BremenGermany D-28334 t Hirnforsch, D-28334 Bremen, Germany Univ Zurich, Abt Neuromorphol, Inst Hirnforsch, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 rsch, CH-8057 Zurich, Switzerland Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 177 - 181
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR HYPOFUNCTION; BEHAVIORAL SENSITIZATION; STARTLE REFLEX; ANIMAL-MODELS; SCHIZOPHRENIA; RAT; PHENCYCLIDINE; AMPHETAMINE; KETAMINE; BRAIN;
Keywords:
addiction; amphetamine; dizocilpine; locomotion; MK-801; schizophrenia; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, M Univ Bremen, Inst Hirnforsch, Postfach 33 04 40, D-28334 Bremen, Germany Univ Bremen Postfach 33 04 40 Bremen Germany D-28334 men, Germany
Citazione:
B. Schulz et al., "Sensitization of prepulse inhibition deficits by repeated administration of dizocilpine", PSYCHOPHAR, 156(2-3), 2001, pp. 177-181

Abstract

Rationale: Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. Objective: We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of the disruptive effects of this compound on prepulse inhibition (PPI) of startle. Methods: Rats received nine daily IP injections of 0.1 mg/kg MK-801 in the startle cage and were tested for PPI, startle in the absence of prepulses and motor activity in the startle cage. Anothergroup of rats received MK-801 in the home cage on 9 days without daily testing. Controls were injected with saline and tested daily, while a separategroup of rats received saline in the home cage without daily testing. On day 10, all rats received saline injections and were tested. On day 11, all rats were injected with 0.1 mg/kg MK-801 and tested again. On day 12, all rats received 1 mg/kg dl-amphetamine IP and were tested for PPI, to assess apossible cross-sensitization. Results: MK-801 had no effect on day 1 of testing but induced a PPI deficit after 6-9 days of daily treatment and testing in those rats that received the drug in the startle cage, but not in thehome cage. Motor activity was increased after repeated treatment and testing. There was also a trend towards sensitization of enhancement of the startle magnitude by MK-801 in these rats. dl-Amphetamine reduced PPI in those rats that received daily MK-801 injections in the startle cage to a similarextent as saline injections. Conclusions: Since PPI is considered as a measure of sensorimotor gating, our data indicate that sensorimotor gating deficits induced by MK-801 are subject to a sensitization process. These findings may be relevant for current hypotheses relating schizophrenic symptoms to sensitization.

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Documento generato il 26/01/20 alle ore 09:50:28