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Titolo:
Effects of psychostimulant withdrawal on latent inhibition of conditioned active avoidance and prepulse inhibition of the acoustic startle response
Autore:
Murphy, CA; Di Iorio, L; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, ETH Zurich, Lab Behav Neurobiol, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 155 - 164
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL EXTRACELLULAR DOPAMINE; MEDIAL PREFRONTAL CORTEX; RAT NUCLEUS-ACCUMBENS; D-AMPHETAMINE; COCAINE WITHDRAWAL; BEHAVIORAL SENSITIZATION; ANTIPSYCHOTIC-DRUGS; RETENTION INTERVAL; REPEATED EXPOSURE; SEXUAL-BEHAVIOR;
Keywords:
amphetamine; cocaine; latent inhibition; prepulse inhibition; withdrawal; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, CA Swiss Fed Inst Technol, ETH Zurich, Lab Behav Neurobiol, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
C.A. Murphy et al., "Effects of psychostimulant withdrawal on latent inhibition of conditioned active avoidance and prepulse inhibition of the acoustic startle response", PSYCHOPHAR, 156(2-3), 2001, pp. 155-164

Abstract

Rationale: Chronic intermittent administration of amphetamine and cocaine can precipitate psychotic episodes in humans and produce persistent behavioral changes (i.e. increased locomotion, stereotypy) in the rat. The psychostimulant sensitization model of psychosis holds that the repeated administration of drugs such as amphetamine and cocaine induces long-lasting neuroadaptations and behavioral outcomes in animals that parallel aspects of the schizophrenic condition. Objectives: In the present study, we attempted to validate this model further by examining the effects of short-term withdrawal from repeated administration of cocaine and amphetamine on performance intwo animal behavioral models of cognitive deficits found in schizophrenia:latent inhibition and prepulse inhibition. Reductions in both of these behavioral phenomena have been reported in schizophrenic patients and in acutely amphetamine-treated rats. Methods: Animals were tested after 4 days of withdrawal from 5 days of daily systemic 20 mg/kg cocaine or 1.5 mg/kg amphetamine injections for either latent inhibition of two-way active avoidance acquisition or prepulse inhibition of an acoustic startle response. Results: Our results indicate that, rather than reducing the expression of these behaviors, withdrawal from either cocaine or amphetamine enhanced the expression of latent inhibition of the active avoidance response while having no effect on prepulse inhibition of acoustic startle. Conclusions: These data indicate that although the sensitized response to amphetamine and cocaine administration may model some aspects of schizophrenic psychosis, behaviors exhibited by sensitized animals in the absence of an acute drug challenge are not consistent with models of the positive symptoms of schizophrenia.

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Documento generato il 20/01/20 alle ore 10:54:02