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Titolo:
Polymorphic repeats in the androgen receptor gene in high-risk sibships
Autore:
Miller, EA; Stanford, JL; Hsu, L; Noonan, E; Ostrander, EA;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Univ Washington, Dept Urol, Seattle, WA 98195 USA Univ Washington SeattleWA USA 98195 on, Dept Urol, Seattle, WA 98195 USA
Titolo Testata:
PROSTATE
fascicolo: 3, volume: 48, anno: 2001,
pagine: 200 - 205
SICI:
0270-4137(20010801)48:3<200:PRITAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-CANCER RISK; CANDIDATE GENES; CAG REPEAT; MEN; MICROSATELLITE; ASSOCIATION;
Keywords:
androgen receptor; genetic polymorphism; prostate cancer; family studies; microsatellites;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Stanford, JL Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N,MW-814, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N,MW-814 Seattle WA USA 98109
Citazione:
E.A. Miller et al., "Polymorphic repeats in the androgen receptor gene in high-risk sibships", PROSTATE, 48(3), 2001, pp. 200-205

Abstract

BACKGROUND. Genetic susceptibility may explain some familial clusters of prostate cancer. The polymorphic androgen receptor (AR) gene, which mediatesandrogen activity in the prostate, is a candidate gene that may influence predisposition to the disease. METHODS. We analyzed the polymorphic (CAG)n and (GGN)n repeats within the AR gene in men from 51 high-risk prostate cancer sibships, which included at least one affected and one unaffected man (n = 210). We compared repeat lengths of men with prostate cancer (n = 140) to their brothers (n = 70) without disease, stratified by median age at diagnosis of affected men within each sibship. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals to evaluate associations between prostate cancer and repeat length. RESULTS. The OR for prostate cancer associated with short (CAG)n repeats (< 22) compared to longer repeats (greater than or equal to 22) was 1.13 (95% CI 0.5-2.4) overall, but was higher in sibships with a median age of < 66years at diagnosis (OR = 1.72, 95% CI 0.5-6.0). The (GGN)n array also was not associated with prostate cancer in general. However, in older men (greater than or equal to 66 years), there was a modest elevation in risk (OR = 1.56, 95% CI 0.6-4.1) among those with short repeats (GGN of less than or equal to 16). Men with both a short (CAG)n (< 22) and a short (GGN)n (less than or equal to 16) array were not at higher risk (OR = 1.06) compared to men with two long repeats [((CAG)n greater than or equal to 22 and (GGN)n > 16)]. CONCLUSIONS. These results suggest that the (CAG)n and (GGN)n repeats in the AR gene do not play a major role in familial prostate cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:58:40