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Titolo:
Hyperploidy of embryonic fibroblasts derived from Parp-1 knockout mouse
Autore:
Nozaki, T; Fujihara, H; Kamada, N; Ueda, O; Takato, T; Nakagama, H; Sugimura, T; Suzuki, H; Masutani, M;
Indirizzi:
Natl Canc Ctr Res Inst, Biochem Div, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Res Inst Tokyo Japan 1040045 Chuo Ku, Tokyo 1040045, Japan Univ Tokyo, Fac Med, Dept Oral & Maxillofacial Surg, Bunkyo Ku, Tokyo 1130032, Japan Univ Tokyo Tokyo Japan 1130032 ial Surg, Bunkyo Ku, Tokyo 1130032, Japan Chugai Pharmaceut Co Ltd, Shizuoka 4120038, Japan Chugai Pharmaceut Co Ltd Shizuoka Japan 4120038 Shizuoka 4120038, Japan
Titolo Testata:
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
fascicolo: 6, volume: 77, anno: 2001,
pagine: 121 - 124
SICI:
0386-2208(200106)77:6<121:HOEFDF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLY(ADP-RIBOSE) POLYMERASE; GENOMIC STABILITY; GENE-DISRUPTION; DNA-DAMAGE; CELLS; MICE; CENTROSOME; INHIBITORS; HOMOLOGS; TUMORS;
Keywords:
Parp; ploidy; endoreduplication; embryonic fibroblast; genomic stability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Masutani, M Natl Canc Ctr Res Inst, Biochem Div, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan Natl Canc Ctr Res Inst 5-1-1 Tsukiji Tokyo Japan 1040045 apan
Citazione:
T. Nozaki et al., "Hyperploidy of embryonic fibroblasts derived from Parp-1 knockout mouse", P JPN AC B, 77(6), 2001, pp. 121-124

Abstract

Various studies show that poly (ADP-ribose) polymerase-1 (Parp-1) is involved in genomic stability. We previously established Parp-1 knockout (Parp-1(-/-)) mice by disrupting Parp-1 exon 1. Parp-1(-/-) and Parp-1(+/+) embryonic fibroblasts were isolated and they became immortalized spontaneously after two months of culture. Parp-1(-/-) embryonic fibroblasts showed extensive hyperploidy compared to Parp-1(+/+) counterparts, and most of the cells contained a single nucleus. These results suggest that disruption of Parp-1could result in the perturbation of chromosomal ploidy control through endoreduplication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:07:56