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Titolo:
Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum
Autore:
Heilmann, J; Brun, R; Mayr, S; Rali, T; Sticher, O;
Indirizzi:
ETH Zurich, Inst Pharmaceut Sci, Dept Appl Biosci, CH-8057 Zurich, Switzerland ETH Zurich Zurich Switzerland CH-8057 iosci, CH-8057 Zurich, Switzerland Swiss Trop Inst, CH-4002 Basel, Switzerland Swiss Trop Inst Basel Switzerland CH-4002 st, CH-4002 Basel, Switzerland PNG Biodivers PTY Ltd, Port Moresby, Papua N Guinea PNG Biodivers PTY LtdPort Moresby Papua N Guinea resby, Papua N Guinea
Titolo Testata:
PHYTOCHEMISTRY
fascicolo: 8, volume: 57, anno: 2001,
pagine: 1281 - 1285
SICI:
0031-9422(200108)57:8<1281:MCAACF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPANOSOMA-BRUCEI; RHODESIENSE; DERIVATIVES; GAMBIENSE;
Keywords:
Amomum aculeatum; Zingiberaceae; 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one; aculeatin D; cytotoxicity; antiprotozoal activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Heilmann, J ETH Zurich, Inst Pharmaceut Sci, Dept Appl Biosci, CH-8057 Zurich, Switzerland ETH Zurich Zurich Switzerland CH-8057 57 Zurich, Switzerland
Citazione:
J. Heilmann et al., "Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum", PHYTOCHEM, 57(8), 2001, pp. 1281-1285

Abstract

A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,2-dien-11-one derivative, aculeatin D, and a new alkenone, 5-hydroxy-hexacos-1-en-3-one, have been isolated as minor compounds from the rhizomes of Amomum aculeatum. Their structures have been determined mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 mug/ml and 1 mug/ml, respectively. Additionally, it revealed remarkable activity against two Plasmodium falciparum strains, as well as against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. 5-Hydroxy-hexacos-1-en-3-one exhibited neither cytotoxic nor antiprotozoal activity, whereas antibacterial testing against Bacillus cereus, Escherichia coli and Staphylococcus epidermidis showed moderate to strong activity for both compounds. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:51:11