Catalogo Articoli (Spogli Riviste)
Titolo: Does lithium exert an independent antisuicidal effect?
Autore: Ahrens, B; Muller-Oerlinghausen, B;
- Free Univ Berlin, Dept Psychiat, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 Psychiat, D-1000 Berlin, Germany
- Titolo Testata:
pagine: 132 - 136
- RECURRENT MOOD DISORDERS; MAINTENANCE TREATMENT; AGGRESSIVE-BEHAVIOR; SUICIDAL-BEHAVIOR; MAJOR DEPRESSION; MORTALITY; CARBAMAZEPINE; RISK; PROPHYLAXIS; SEROTONIN;
- Tipo documento:
- Settore Disciplinare:
- Life Sciences
- Indirizzi per estratti:
- Indirizzo: Ahrens, B Univ Lubeck, Dept Psychiat, Ratzeburger Allee 160, D-23538 Lubeck, Germany Univ Lubeck Ratzeburger Allee 160 Lubeck Germany D-23538 ermany
- B. Ahrens e B. Muller-Oerlinghausen, "Does lithium exert an independent antisuicidal effect?", PHARMACOPS, 34(4), 2001, pp. 132-136
Abstract Aim of study: Recent investigations have indicated that adequate lithium treatment lowers the suicide mortality associated with affective illness. One important question is whether the mechanism by which lithium prophylaxis may be effective in prolonging survival can be explained exclusively in terms of successful protection against the recurrence of depressive episodes, or whether one should consider an independent anti-suicidal factor. Methods: We investigated a group of high-risk patients with recurrent affective disorders (n = 167) who had committed one or more suicide attempts before thestart of lithium prophylaxis within a collaborative project by the International Group for the Study of Lithium Treated Patients (IGSLI). According to their recurrence-related response to long-term lithium prophylaxis, patients were classified into three groups: excellent (n = 45), moderate (n = 81) and poor responders (n = 41). Only depressive episodes resulting into hospitalisation were considered. A marked reduction in the number of suicide attempts was observed in the excellent lithium responders. However, we also found that over 80% of moderate responders and nearly 50% of poor responders did not exhibit any further suicidal behaviour during lithium treatment. Furthermore, we could demonstrate a significant reduction of suicide attempts per year as compared to a corresponding pre-lithium period in all three groups (0.10 vs. 0.33, 0.06 vs. 0.27, 0.02 vs. 0.26). There were four suicides in this high-risk group, corresponding to a suicide-related standardised mortality ratio (SMR) of 13.7. This contrasts sharply with an expected suicide SMR of approx. 100 in this population. Suicide risk was not related to the recurrence-preventing effect. Conclusion: The reduction in suicide attempts, in both responders and non-responders, indicates that lithium possesses a specific anti-suicidal effect besides its mood-stabilising property.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:10:08