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Titolo:
Hypericum extract and hyperforin: Memory-enhancing properties in rodents
Autore:
Klusa, V; Germane, S; Noldner, M; Chatterjee, SS;
Indirizzi:
Latvian State Univ, Fac Med, Dept Pharmacol, LV-1001 Riga, Latvia Latvian State Univ Riga Latvia LV-1001 t Pharmacol, LV-1001 Riga, Latvia Latvian Inst Organ Synth, Pharmacol Lab, Riga, Latvia Latvian Inst Organ Synth Riga Latvia Synth, Pharmacol Lab, Riga, Latvia Dr Willmar Schwabe GmbH & Co, Dept Pharmacol, Karlsruhe, Germany Dr Willmar Schwabe GmbH & Co Karlsruhe Germany acol, Karlsruhe, Germany
Titolo Testata:
PHARMACOPSYCHIATRY
, volume: 34, anno: 2001, supplemento:, 1
pagine: S61 - S69
SICI:
0176-3679(200107)34:<S61:HEAHMP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ST-JOHNS-WORT; FORCED SWIMMING TEST; ANTIDEPRESSANT ACTIVITY; ALZHEIMERS-DISEASE; DEPRESSED-PATIENTS; COGNITIVE DECLINE; CLINICAL-TRIALS; RISK-FACTORS; PERFORATUM; CONSTITUENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Klusa, V Latvian State Univ, Fac Med, Dept Pharmacol, Sarlotes St 1A, LV-1001 Riga,Latvia Latvian State Univ Sarlotes St 1A Riga Latvia LV-1001 iga,Latvia
Citazione:
V. Klusa et al., "Hypericum extract and hyperforin: Memory-enhancing properties in rodents", PHARMACOPS, 34, 2001, pp. S61-S69

Abstract

Effects of a Hypericum extract in therapeutic use and hyperforin sodium salt were evaluated in rat and mouse avoidance tests. In a conditioned avoidance response (CAR) test on the rat, oral daily administration of hyperforin(1.25 mg/kg/day) or of the extract (50 mg/kg/day) before the training sessions considerably improved learning ability from the second day onwards until the day 7. In addition, the memory of the learned responses acquired during 7 consecutive days of administration and training was largely retained even after 9 days without further treatment or training. The observations made using different doses indicate that these learning-facilitating and/or memory-consolidating effects by the agents follow inverse U-shaped dose-response curves in dose ranges lower than (for hyperforin) or equal to (for Hypericum extract) their effective dose in the behavioral despair test for antidepressants. In a passive avoidance response test on the mouse, a single oral dose (1.25 mg/kg) of hyperforin not only improved memory acquisition and consolidation, but also almost completely reversed scopolamine-induced amnesia. The single Hypericum extract dose tested (25 mg/kg) did not reveal any significant effects in the passive avoidance response (PAR) test on themouse. These observations suggest that the Hypericum extract could be a novel type of antidepressant with memory enhancing properties, and indicate that hyperforin is involved in its cognitive effects. Pure hyperforin seems to be a more potent antidementia agent than an antidepressant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 07:58:02