Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment
Autore:
Butterweck, V; Korte, B; Winterhoff, H;
Indirizzi:
Inst Pharmakol & Toxikol, D-48149 Munster, Germany Inst Pharmakol & Toxikol Munster Germany D-48149 -48149 Munster, Germany
Titolo Testata:
PHARMACOPSYCHIATRY
, volume: 34, anno: 2001, supplemento:, 1
pagine: S2 - S7
SICI:
0176-3679(200107)34:<S2:PAEEOH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; BEHAVIORAL DESPAIR TEST; ADRENAL-GLAND VOLUME; FORCED SWIMMING TEST; ANTIDEPRESSANT ACTIVITY; DEPRESSED-PATIENTS; THERAPEUTIC IMPLICATIONS; TYROSINE-HYDROXYLASE; ANTI-DEPRESSANTS; MAJOR DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Butterweck, V Inst Pharmakol & Toxikol, Domagkstr 12, D-48149 Munster, Germany Inst Pharmakol & Toxikol Domagkstr 12 Munster Germany D-48149
Citazione:
V. Butterweck et al., "Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment", PHARMACOPS, 34, 2001, pp. S2-S7

Abstract

Clinical studies have demonstrated the antidepressant efficacy of Hypericum (St. John's wort) extracts comparable to tricyclic antidepressants such as imipramine. We examined the effects of Hypericum extract and hypericin, one active constituent, in the forced swimming test (FST) after treatment repeated for 14 days. it has recently been shown that hypericin was inactive in the FST after acute treatment, but remarkably active when solubilized bysubfraction IIIc(1) containing mainly procyanidin B2. Therefore, we investigated the cooperative effects of hypericin and procyanidin B2 after repeated treatment. Imipramine (15 mg/kg), Hypericum extract (500 mg/kg) and hypericin (0.1 mg/kg) given daily for 2 weeks significantly reduced immobility time in the FST. No differences were observed between animals receiving pure hypericin and those receiving hypericin in combination with procyanidin B2. As several antidepressants act on the neuroendocrine axis resulting in altered hormone concentrations, selected endocrine parameters were investigated after repeated treatment. Daily treatment with either imipramine, Hypericum extract or hypericin alone or in combination with procyanidin B2 for 14 days significantly decreased plasma ACTH and corticosterone levels. None of the substances had pronounced effects on plasma prolactin or LH levels. From our present data, we propose that cooperative effects of hypericin andprocyanidin B2 are of important relevance for the acute, but not for the chronic effects of this polycylic quinone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:46:56