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Titolo:
MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning
Autore:
Harrod, SB; Flint, RW; Riccio, DC;
Indirizzi:
Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 ept Psychol, Lexington, KY 40506 USA Coll St Rose, Dept Psychol, Albany, NY 12203 USA Coll St Rose Albany NY USA 12203 Rose, Dept Psychol, Albany, NY 12203 USA Kent State Univ, Dept Psychol, Kent, OH 44242 USA Kent State Univ Kent OHUSA 44242 Univ, Dept Psychol, Kent, OH 44242 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3-4, volume: 69, anno: 2001,
pagine: 585 - 593
SICI:
0091-3057(200107/08)69:3-4<585:MIRBNA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST MK-801; LONG-TERM POTENTIATION; NMDA RECEPTOR; SPATIAL MEMORY; NITRIC-OXIDE; RATS; FEAR; EXTINCTION; RETENTION; AMYGDALA;
Keywords:
MK-801; NMDA receptor antagonist; state-dependent retention; passive avoidance; learning; memory; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Harrod, SB Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 , Lexington, KY 40506 USA
Citazione:
S.B. Harrod et al., "MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning", PHARM BIO B, 69(3-4), 2001, pp. 585-593

Abstract

Two experiments using a state-dependent retention (SDR) design determined whether MK-801 blocked the acquisition and retention of an avoidance response. In Experiments 1 and 2, rats were trained and tested 30 min after injections of either saline or MK-801 (0.05 and 0.10 mg/kg, respectively). Two minutes after training, subjects were immediately tested, and in both experiments, the avoidance response was acquired. The 24-h retention tests for Experiment 1 revealed that the data marginally supported a SDR interpretation. In Experiment 2, the dose of MK-801 was increased to 0.10 mg/kg, and the results showed that NIK-801 rendered passive avoidance (PA) state-dependent. These experiments indicate that neither the 0.05 nor 0.10 mg/kg doses of MK-801 prevented acquisition of the avoidance response and that the latter dose rendered memory for PA training state-dependent. It is suggested that doses of MK-801 that did not impair PA learning can function as a cue stateand influence expression of memory for PA. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 25/01/20 alle ore 18:32:19