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Titolo:
Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring rats
Autore:
Smith, DG; Learn, JE; McBride, WJ; Lumeng, L; Li, TK; Murphy, JM;
Indirizzi:
Indiana Univ, Sch Med, Program Med Neurobiol, Dept Psychiat,Inst Psychiat Res, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 at Res, Indianapolis, IN 46202 USA Indiana Univ Purdue Univ, Purdue Sch Sci, Dept Psychol, Program PsychobiolAddict, Indianapolis, IN 46202 USA Indiana Univ Purdue Univ Indianapolis IN USA 46202 anapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Biochem, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iochem, Indianapolis, IN 46202 USA Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN 46202 USA Richard L Roudebush Vet Adm Med Ctr Indianapolis IN USA 46202 N 46202 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3-4, volume: 69, anno: 2001,
pagine: 543 - 553
SICI:
0091-3057(200107/08)69:3-4<543:LEOADO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREE-CHOICE DRINKING; DOPAMINE RELEASE; MOVING RATS; P-LINE; FUNCTIONAL CONSEQUENCES; NUCLEUS-ACCUMBENS; ETHANOL INTAKE; SELF-INFUSION; ANIMAL-MODELS;
Keywords:
local cerebral glucose utilization; chronic alcohol drinking; alcohol deprivation; alcohol-preferring rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: McBride, WJ Indiana Univ, Sch Med, Program Med Neurobiol, Dept Psychiat,Inst Psychiat Res, 791 Union Dr, Indianapolis, IN 46202 USA Indiana Univ 791 Union Dr Indianapolis IN USA 46202 46202 USA
Citazione:
D.G. Smith et al., "Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring rats", PHARM BIO B, 69(3-4), 2001, pp. 543-553

Abstract

The 2-[C-14]deoxyglucose (2-DG) quantitative autoradiography technique wasused to determine rates of local cerebral glucose utilization (LCGU) in discrete brain regions in alcohol-chronic (A-C), alcohol-deprived (A-D) and alcohol-naive (A-N) adult, male alcohol-preferring (P) rats. The hypothesis to be tested is that neuronal alterations occur as a result of chronic alcohol drinking and some of these alterations persist for long periods in the absence of alcohol. Following 6 weeks of daily 4-h scheduled access sessions to 15% (v/v) ethanol and water, group A-D received only water during the sessions over the next 2 weeks, whereas groups A-C and A-N continued to receive ethanol-water and water-water, respectively. On the 14th day of the deprivation interval, LCGU rates were measured 1 h prior to the scheduled access period. Mean ethanol intake for the A-D and A-C groups was 1.5 +/- 0.1 g ethanol/kg body weight per 4 h. LCGU rates were significantly decreased in 49 of 57 regions or subregions examined in the A-C group compared to the A-N group, including subregions of the cerebral cortex, hippocampus and structures in the mesocorticolimbic and nigrostriatal systems. Following alcohol deprivation, LCGU values in the A-D group were partially or completely returned to A-N levels in many, but not all, regions. In several limbic regions (e.g., ventral tegmental area, olfactory tubercle, medial prefrontal cortex, ventral pallidum and lateral septum), no recovery of LCGU rates was observed after 2 weeks of alcohol deprivation. This study demonstrates that chronic alcohol consumption produces significant reductions in functional neuronal activity in P rats, some of which persist in the absence of ethanol. The extent to which LCGU rates returned to normal levels following 2 weeks of alcohol deprivation varied among brain regions, suggesting that there are imbalanced interactions among and within several CNS sites, which do not reflect either the alcohol-naive or chronic alcohol-exposed state. Such neuronal imbalances may underlie relapse of alcohol drinking following prolonged abstinence. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:13:18