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Titolo:
Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups
Autore:
Hennessy, MB; Pitstick, L; OLeary, S; Maken, DS; Farre, AJ;
Indirizzi:
Wright State Univ, Dept Psychol, Dayton, OH 45435 USA Wright State Univ Dayton OH USA 45435 Dept Psychol, Dayton, OH 45435 USA Labs Dr ESTEVE, CNS Res, SA, Barcelona, Spain Labs Dr ESTEVE Barcelona Spain Dr ESTEVE, CNS Res, SA, Barcelona, Spain
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3-4, volume: 69, anno: 2001,
pagine: 527 - 533
SICI:
0091-3057(200107/08)69:3-4<527:EOANPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P RECEPTORS; MATERNAL SEPARATION; NONPEPTIDE ANTAGONIST; LOCOMOTOR-ACTIVITY; FACTOR CRF; STRESS; DEPRESSION; INHIBITION; RAT; VOCALIZATIONS;
Keywords:
antidepressant; isolation; vocalizations; cortisol; guinea pigs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Hennessy, MB Wright State Univ, Dept Psychol, Dayton, OH 45435 USA Wright State Univ Dayton OH USA 45435 , Dayton, OH 45435 USA
Citazione:
M.B. Hennessy et al., "Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups", PHARM BIO B, 69(3-4), 2001, pp. 527-533

Abstract

A novel, potential antidepressant, E-6006 citrate (E-6039), dose-dependently reduced the vocalizations emitted by isolated guinea pig pups. The (+)-E-6006, but not the ( -)-E-6006, enantiomer also reduced vocalizing. There were no reliable effects of E-6039 on locomotor activity, crouching, or other behavioral measures, but both E-6039 and the (+)-E-6006 enantiomer elevated plasma cortisol levels during isolation. The contrasting effects of E-6039 on vocalizations and plasma cortisol are discussed in terms of E-6039's putative ability to inhibit release of substance P. The reduction in the vocalizations of isolated guinea pig pups corroborates positive results with this drag in other antidepressant screens utilizing mice and rats, and provides further support for the potential of E-6039 as an antidepressant compound. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 27/01/20 alle ore 13:57:47