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Titolo:
The role of NMDA receptors in neonatal cocaine-induced neurotoxicity
Autore:
Huber, JD; Darling, SF; Park, KK; Soliman, KFA;
Indirizzi:
Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA Florida A&M Univ Tallahassee FL USA 32307 Sci, Tallahassee, FL 32307 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3-4, volume: 69, anno: 2001,
pagine: 451 - 459
SICI:
0091-3057(200107/08)69:3-4<451:TRONRI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENTAL LEAD-EXPOSURE; PITUITARY-ADRENAL AXIS; RAT HIPPOCAMPAL SLICES; METHYL-D-ASPARTATE; PYRAMIDAL NEURONS; DOPAMINE NEURONS; STRESS; MK-801; MODELS; PERFORMANCE;
Keywords:
cocaine; NMDA; MK-801; neonatal; stress; pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Soliman, KFA Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA Florida A&M Univ Tallahassee FL USA 32307 ssee, FL 32307 USA
Citazione:
J.D. Huber et al., "The role of NMDA receptors in neonatal cocaine-induced neurotoxicity", PHARM BIO B, 69(3-4), 2001, pp. 451-459

Abstract

The present study assessed the ability of N-methyl-D-aspartate (NMDA) receptor antagonist, dizocilpine (MK-801), to modulate neonatal cocaine-inducedneurobehavioral changes in the rat. Sprague-Dawley rats were randomly assigned on postnatal day 0 (PND 0) to one of four treatment groups. Treatmentsbegan on PND 4 and continued until PND 10. Treatments consisted of an oralbolus of either cocaine HCl (40 mg/kg), (+)MK-801 (0.4 mg/kg), (+)MK-801 (0.4 mg/kg) followed 30 min later with cocaine HCl (40 mg/kg) or 0.9% saline. On PND 21, 30, 40 and 60, males and females were examined for stress response using the cold-water swim test. Cocaine-treated male and female rats exhibited significantly diminished tolerance to cold-water stress compared to control and MK-801/cocaine-treated groups. In addition, neonatal exposureto cocaine was associated with increased severity of motor symptoms (tail twitches, wet dog shaking and convulsions) following the administration of NMDA (35 mg/kg). Treatment groups were also tested for pain sensitivity using the tail flick (TF) and hot plate (HP) methods. The results indicated that neonatal cocaine exposure altered pain sensitivity in both tests. NMDA receptor binding studies showed a significant increase in receptor densitiesin the hippocampus and hypothalamus of the cocaine-treated group compared to control. MK-801 administered to rat pups before cocaine treatment blocked the increase in receptor density. The results indicated that neonatal cocaine exposure was associated with altered responses to NMDA, stress tolerance and pain sensitivity. Moreover, the pretreatment with NMDA receptor antagonist, MK-801, abolished or attenuated these cocaine-induced neurobehavioral changes. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:27:23