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Titolo:
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
Autore:
Nowend, KL; Arizzi, M; Carlson, BB; Salamone, JD;
Indirizzi:
Univ Connecticut, Dept Psychol, Unit 1020, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 hol, Unit 1020, Storrs, CT 06269 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3-4, volume: 69, anno: 2001,
pagine: 373 - 382
SICI:
0091-3057(200107/08)69:3-4<373:DODAIN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTROLATERAL STRIATAL DOPAMINE; INSTRUMENTAL RESPONSE SELECTION; PROGRESSIVE-RATIO PERFORMANCE; LOCOMOTOR-ACTIVITY; FEEDING-BEHAVIOR; OPERANT-BEHAVIOR; CHOICE PROCEDURE; D-2 RECEPTORS; DEPLETIONS; HALOPERIDOL;
Keywords:
operant; instrumental; behavior; reinforcement; motivation; dopamine; behavioral economics; reward;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Salamone, JD Univ Connecticut, Dept Psychol, Unit 1020, 406 Babbidge Rd, Storrs, CT 06269 USA Univ Connecticut 406 Babbidge Rd Storrs CT USA 06269 6269 USA
Citazione:
K.L. Nowend et al., "D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption", PHARM BIO B, 69(3-4), 2001, pp. 373-382

Abstract

Although interference with dopamine (DA) systems can suppress lever pressing for food reinforcement, it is not clear whether this effect occurs because of a general disruption of food motivation. One way of assessing this has been a choice procedure in which a rat responds on an fixed ratio 5 (FR5)schedule for preferred Bioserve pellets while a less preferred lab chow isconcurrently available in the operant chamber. Untreated rats consume little of the chow, preferring to respond for the Bioserve pellets. Previous studies have shown that depleting DA in the accumbens substantially decreasedlever pressing while increasing chow consumption. In the present study, low doses (0.0625- 1.0 mug) of the D1 antagonist SCH 23390 or the D2 antagonist raclopride were injected into the either the core or shell subregions ofnucleus accumbens, and rats were tested on the concurrent lever pressing/feeding task. Analysis of the dose response curves showed that injections ofSCH 23390 into the core were more potent than injections into the shell for suppressing lever pressing (i.e., the ED50 was lower in the core). Nevertheless, injections of either drug into either site suppressed lever pressing and increased intake of the concurrently available chow. Across both drugs and at both sites, the amount of chow consumed was negatively correlated with the total number of responses. Neither drug significantly increased response duration, suggesting that accumbens DA antagonism did not produce the type of motor impairment that leads to severe alterations in the form of lever pressing. In summary, the blockade of D1 or D2 receptors in nucleus accumbens core or shell decreased lever pressing for food reinforcers, but rats remained directed toward the acquisition and consumption of food. Theseresults indicate that accumbens D1 antagonism does not decrease lever pressing because of a general reduction in food motivation. Nevertheless, interference with accumbens DA does appear to set constraints upon which responses are selected for obtaining food, and may impair the ability of animals to overcome work-related response costs in order to obtain food. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:19:17