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Titolo:
Chronic corticosterone treatment alters sensory gating in C3H mice
Autore:
Stevens, KE; Bullock, AE; Collins, AC;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado, Dept Psychol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 o, Dept Psychol, Boulder, CO 80309 USA Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3-4, volume: 69, anno: 2001,
pagine: 359 - 366
SICI:
0091-3057(200107/08)69:3-4<359:CCTASG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-BUNGAROTOXIN-BINDING; NICOTINIC CHOLINERGIC RECEPTORS; INBRED MOUSE STRAINS; PREPULSE INHIBITION; ACOUSTIC STARTLE; SCHIZOPHRENIC-PATIENTS; DOPAMINE TRANSPORTER; STRIATAL NEURONS; AUDITORY-STIMULI; CHANNEL DOMAIN;
Keywords:
prepulse inhibition; acoustic startle; sensorimotor gating; sensory gating; sensory inhibition; auditory gating; schizophrenia; nicotine; nicotinic receptors; alpha-bungarotoxin; corticosterone; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Stevens, KE Univ Colorado, Hlth Sci Ctr, Dept Psychiat, 4200 E 9th Ave, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262 CO 80262 USA
Citazione:
K.E. Stevens et al., "Chronic corticosterone treatment alters sensory gating in C3H mice", PHARM BIO B, 69(3-4), 2001, pp. 359-366

Abstract

Two methods of evaluating inhibitory sensory processing are prepulse inhibition of acoustic startle (PPI) and gating of auditory evoked potentials. Studies using both methods suggest nicotinic acetylcholinergic receptor modulation of gating, specifically the alpha -bungarotoxin (alpha -BTX) bindingsite (alpha7 receptor subtype). However, recent assessment of alpha7 null mutant mice failed to demonstrate any effect of the loss of this receptor in either gating paradigm. An alternate approach to assessing the effects ofthe alpha7 receptor is to reduce its numbers in mature inbred mice, thus, avoiding the twin problems of background and developmental compensation inherent in null mutant mouse studies. Numerous studies have shown that chronic corticosterone (CCS) treatment selectively reduces alpha -BTX binding sites. C3H mice were adrenalectomized and implanted with corticosterone or cholesterol (control) pellets. After 8 days, they were tested in one of the gating paradigms. PPI and auditory gating were significantly diminished in corticosterone-treated mice concomitant with a reduction in alpha -BTX binding in several brain regions. Cholesterol-treated mice had no change in either paradigm. Nicotine treatment (1 mg/kg) produced significant improvement in both paradigms in corticosterone-treated mice. These data agree with previous pharmacological studies suggesting modulation of gating occurs througha nicotinic receptor. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:22:52