Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intratracheal administration of perfluorochemical-gentamicin suspension: Acomparison to intravenous administration in normal and injured lungs
Autore:
Cox, CA; Cullen, AB; Wolfson, MR; Shaffer, TH;
Indirizzi:
Bryn Mawr Hosp, Bryn Mawr, PA USA Bryn Mawr Hosp Bryn Mawr PA USABryn Mawr Hosp, Bryn Mawr, PA USA Temple Univ, Dept Physiol & Pediat, Philadelphia, PA 19122 USA Temple Univ Philadelphia PA USA 19122 Pediat, Philadelphia, PA 19122 USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 2, volume: 32, anno: 2001,
pagine: 142 - 151
SICI:
8755-6863(200108)32:2<142:IAOPSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL LIQUID VENTILATION; RESPIRATORY-DISTRESS SYNDROME; HOSPITAL-ACQUIRED PNEUMONIA; PULMONARY BLOOD-FLOW; THERAPEUTIC AEROSOLS; ASSISTED VENTILATION; ANTIMICROBIAL AGENTS; GUINEA-PIGS; INHALATION; SURFACTANT;
Keywords:
gentamicin; intratracheal; intravenous; partial liquid ventilation; perfluorochemical fluid; animal model; neonatology; perfluorochemical-gentamicin suspension; lung injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Shaffer, TH Alfred I duPont Hosp Children, Nemours Lung Ctr, POB 269, Wilmington, DE 19899 USA Alfred I duPont Hosp Children POB 269 Wilmington DE USA 19899
Citazione:
C.A. Cox et al., "Intratracheal administration of perfluorochemical-gentamicin suspension: Acomparison to intravenous administration in normal and injured lungs", PEDIAT PULM, 32(2), 2001, pp. 142-151

Abstract

Respiratory infections can lead to acute lung injury and perfusion abnormalities. We hypothesized that intratracheal (IT) administration of a perfluorochemical (PFC) gentamicin (G) suspension as compared to intravenous (IV) administration of gentamicin will result in higher lung tissue levels of gentamicin, while maintaining safe serum levels. To test this hypothesis, 21 lambs with normal and acid injured lungs were studied for 4 hr, using 2 different drug delivery methods, IT and IV. Lungs were injured with warm HCl acid in saline lavage, followed by partial liquid ventilation with perflubron (bolus FRC = 20 mL/kg). G at a dose of 5 mg/kg was delivered either IT (G-PFC; 20 mL/kg) or IV (aqueous injection with IT 20 mL/kg PFC alone). Throughout the study, serum G levels, arterial blood gases, respiratory system compliance, and mean arterial blood pressure were measured. Lung tissue G levels were measured at 4 hr and averaged across lobes. Physiologic gas exchange and pulmonary function were maintained throughout the protocol for boththe normal and injured lungs. Intravenously administered G resulted in an initial 5-min serum concentration of 43 +/- 2.5 mcg/ mL, followed by an exponential decline over the 4-hrprotocol to a level of 2.1 +/- 0.23 mcg/mL at hr 4. The intratracheally administered G suspension resulted in a 5-min serum concentration of 1.8 +/- 0.98 mcg/mL and remained relatively constant throughout the protocol, with a 4-hr level of 1.6 +/- 0.29 mcg/mL. With respect to lung tissue G levels, IT administration was significantly more effective in delivering the drug to the normal lungs than IV (31.4 +/- 3.3 mcg/g vs. 4.0 +/- 0.7 mcg/g) 4 hr after administration, In the lung injury group, there was a small but significant difference in lung tissue G levels, with the IT-administered perfluorochemical-G suspension achieving greater levels than the IV-administered G(11.9 +/- 0.52 mcg/g vs. 10.1 +/- 0.8 mcg/g). Additionally, the drug delivered IV and IT in both the normal and injured lung models was homogeneouslydistributed throughout the lung. These data show that G lung tissue levels in both normal and injured lungswere higher in the IT group when compared to IV administration. The results of this study demonstrate that in normal and injured lungs, homogeneous Glung tissue levels can be more effectively achieved at lower serum levels when delivered IT in a G-PFC suspension as compared to IV administration. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:43:55