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Titolo:
Combined pharmacotherapy for nocturnal enuresis
Autore:
Kaneko, K; Fujinaga, S; Ohtomo, Y; Shimizu, T; Yamashiro, Y;
Indirizzi:
Juntendo Univ, Sch Med, Dept Pediat, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ediat, Bunkyo Ku, Tokyo 1138421, Japan
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 8, volume: 16, anno: 2001,
pagine: 662 - 664
SICI:
0931-041X(200108)16:8<662:CPFNE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYBUTYNIN; INCONTINENCE; THERAPY; TRIAL;
Keywords:
enuresis; amitriptyline; imipramine; oxybutinin; propiverine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneko, K Juntendo Univ, Sch Med, Dept Pediat, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 yo 1138421, Japan
Citazione:
K. Kaneko et al., "Combined pharmacotherapy for nocturnal enuresis", PED NEPHROL, 16(8), 2001, pp. 662-664

Abstract

Nocturnal enuresis is a common childhood disorder. Tricyclic antidepressants and anticholinergic agents have been the well accepted pharmacological treatment for this disorder and are efficacious in 40-70% and 10-50% of cases, respectively. The present study was performed to evaluate the effect of a combined treatment of tricyclic antidepressant and an anticholinergic agent. Twenty-two children aged 6-12 years with primary monosymptomatic nocturnal enuresis who did not prefer to use a conditioning alarm were given a combined treatment of these drugs. After a control period of 1 month, each patient was treated for 6 months and then observed for 3 months. A 30-mg doseof amitriptyline or imipramine was given with either 2-4 mg oxybutinin or 10-20 mg, propiverine. Efficacy was determined relative to the number of wet nights per week compared with the control period, with more than a 50% decrease in wet nights per week taken to indicate efficacy. The mean wet nights per week decreased from 6.1 to 1.7 (P<0.01), and efficacy was established in 20 patients (90.9%). Relapses occurred in 60.0% of patients during thefollow-up period. No significant side effects were observed. The efficacy of the combined therapy in monosymptomatic nocturnal enuresis appears to begreater than that reported for either drug alone, and therefore can be a choice of treatment in order to motivate children with nocturnal enuresis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:40:48