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Titolo:
The roles of the N-terminal portions of various tachykinins in promoting salivation
Autore:
Higa, K; Gao, C; Motokawa, W; Abe, K;
Indirizzi:
Fukuoka Dent Coll, Dept Pediat Dent, Fukuoka 8140193, Japan Fukuoka Dent Coll Fukuoka Japan 8140193 iat Dent, Fukuoka 8140193, Japan Fukuoka Dent Coll, Dept Oral Biochem, Fukuoka 8140193, Japan Fukuoka Dent Coll Fukuoka Japan 8140193 Biochem, Fukuoka 8140193, Japan
Titolo Testata:
ORAL DISEASES
fascicolo: 4, volume: 7, anno: 2001,
pagine: 238 - 245
SICI:
1354-523X(200107)7:4<238:TROTNP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SUBMANDIBULAR GLANDS; SUBSTANCE-P; PROTEIN SECRETION; NEUROKININ-B; SELECTIVE AGONISTS; PAROTID-GLANDS; RECEPTOR; ELECTROLYTES; DERIVATIVES; MECHANISM;
Keywords:
sialogogic peptides; kassinin; neurokinins A and B; N-terminal portion; active site; rat saliva;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Higa, K Fukuoka Dent Coll, Dept Pediat Dent, Fukuoka 8140193, Japan Fukuoka Dent Coll Fukuoka Japan 8140193 , Fukuoka 8140193, Japan
Citazione:
K. Higa et al., "The roles of the N-terminal portions of various tachykinins in promoting salivation", ORAL DIS, 7(4), 2001, pp. 238-245

Abstract

OBJECTIVES: In order to determine the active sites for salivation of various tachykinins, the regulatory roles of the N-terminal portion of various newly-synthesized tachykinins were studied after i.p. injection of rats using the submandibular glands as model organs. METHODS: N-shortened oligopeptides from kassinin, eledoisin, neurokinins A(NKA) and NKB were synthesized by the multipin peptide synthesis method. Amino acids were eliminated one by one to form octa- to undeca-peptides adjoining the inactive or less active heptapeptides and various heptapeptides, in which an amino acid in position 8 (Xaa(8)), numbering as in an undecapeptide, was replaced with Tyr, Phe, lie or Val. RESULTS: The N-terminal amino acids in positions I to 4 could be activators or inhibitors, depending on whether the C-terminal heptapeptide was inactive or less active. The Xaa(8) residue, in combination with amino acids in positions 5 and 6, seemed to be very important in determining the sialogogic activity of a heptapeptide. The discrimination between NKA and NKB appeared due to the N-terminal amino acid sequence in positions 1 to 4 including Phe or Ser in position 6. CONCLUSIONS: It is concluded that the N-terminal amino acids in positions 1 to 4 serve as either activators or inhibitors depending upon the sialogogic activity of the C-terminal heptapeptide, in which particular amino acidsin positions 5, 6 and 8 regulate its activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:41:04