Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Associations of plasma aflatoxin B-1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1
Autore:
Chen, SY; Chen, CJ; Tsai, WY; Ahsan, H; Liu, TY; Lin, JT; Santella, RM;
Indirizzi:
Columbia Univ, Sch Publ Hlth, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Sch Publ Hlth, New York, NY 10032 USA Nalt Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10018, Taiwan Nalt Taiwan Univ Taipei Taiwan 10018 nst Epidemiol, Taipei 10018, Taiwan Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10018, Taiwan Natl TaiwanUniv Hosp Taipei Taiwan 10018 rnal Med, Taipei 10018, Taiwan Hlth Bur Lienkiang Cty, Matzu, Taiwan Hlth Bur Lienkiang Cty Matzu Taiwan th Bur Lienkiang Cty, Matzu, Taiwan
Titolo Testata:
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
fascicolo: 2, volume: 38, anno: 2000,
pagine: 179 - 185
SICI:
0163-5581(2000)38:2<179:AOPABA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-B VIRUS; PERFORMANCE LIQUID-CHROMATOGRAPHY; HEPATOCELLULAR-CARCINOMA; ALBUMIN ADDUCTS; METABOLIZING ENZYMES; SURFACE-ANTIGEN; INCREASED RISK; C VIRUSES; LIVER; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Santella, RM Columbia Univ, Sch Publ Hlth, New York, NY 10032 USA ColumbiaUniv New York NY USA 10032 , New York, NY 10032 USA
Citazione:
S.Y. Chen et al., "Associations of plasma aflatoxin B-1-albumin adduct level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1", NUTR CANCER, 38(2), 2000, pp. 179-185

Abstract

Mortality from hepatocellular carcinoma (HCC) is extraordinarily high in Matzu, an island off the coast of Southeastern China. To investigate factorsassociated with plasma aflatoxin B-1 (AFB(1))-albumin adduct level, we studied 304 healthy adult residents from Matzu. AFB(1)-albumin adducts were determined by competitive enzyme-linked immunosorbent assay, hepatitis B surface antigen status by enzyme immunoassay, genotypes of glutathione S-transferase (GST) M1 and T1 by polymerase chain reaction, plasma selenium by atomic absorption spectrometry, and plasma retinol, alpha -tocopherol, alpha -carotene, and beta -carotene levels by high-performance liquid chromatography. Men had higher AFB(1)-albumin adduct levels than women. GSTM1-nonnull and GSTT1-null genotypes and low plasma selenium level were significantly associated with an increased level of AFB(1)-albumin adducts among men, whereas age was significantly correlated with adduct level among women. High intake of fermented beans was associated with an increased adduct level among men and women. The inverse associations between plasma selenium level and AFB(1)-albumin adducts were statistically significant among those with null genotypes of GSTM1 and GSTT1, but not among the nonnull genotypes. This study provides insight into the dietary and genetic factors influencing AFB(1)-albumin adduct formation in an isolated population with high liver cancer mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:28:02