Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease
Autore:
Alvarez, R; Gonzalez, P; Batalla, A; Reguero, JR; Iglesias-Cubero, G; Hevia, S; Cortina, A; Merino, E; Gonzalez, I; Alvarez, V; Coto, E;
Indirizzi:
Hosp Cent Asturias, Mol Genet Lab, Inst Invest Nefrol, Oviedo 33006, SpainHosp Cent Asturias Oviedo Spain 33006 Invest Nefrol, Oviedo 33006, Spain Hosp Cent Asturias, Serv Cardiol, Oviedo 33006, Spain Hosp Cent Asturias Oviedo Spain 33006 Serv Cardiol, Oviedo 33006, Spain
Titolo Testata:
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
fascicolo: 4, volume: 5, anno: 2001,
pagine: 343 - 348
SICI:
1089-8603(200108)5:4<343:ABTN(T>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-CONVERTING ENZYME; LONG-TERM BLOCKADE; MYOCARDIAL-INFARCTION; GENE POLYMORPHISM; ESSENTIAL-HYPERTENSION; DELETION POLYMORPHISM; RELAXING FACTOR; RISK FACTOR; ENDOTHELIUM;
Keywords:
endothelial constitutive nitric oxide synthase; angiotensin I converting enzyme; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Coto, E Hosp Cent Asturias, Mol Genet Lab, Inst Invest Nefrol, Oviedo 33006, Spain Hosp Cent Asturias Oviedo Spain 33006 efrol, Oviedo 33006, Spain
Citazione:
R. Alvarez et al., "Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease", NITRIC OXID, 5(4), 2001, pp. 343-348

Abstract

DNA polymorphisms at the endothelium. constitutive nitric oxide synthase gene (NOS3) have been linked to the risk of developing coronary artery disease (CAD). In vitro, a polymorphism in the 5' region of the NOS3 gene (-786 T/C) influences promoter activity. This polymorphism has been associated with coronary spasms among Japanese. The genetic variation at the angiotensin-converting enzyme (ACE) is associated with plasma ACE activities and has also been linked with susceptibility to cardiovascular disease. Our objective was to determine if DNA polymorphisms in the NOS3 and ACE genes were associated with early CAD. We analyzed the -786 T/C polymorphism in the 5' flanking region and the 27-bp repeat polymorphism in NOS3 intron 4, as well as the ACE-LID polymorphism. A total of 170 male smokers (CAD patients) younger than 50 years and 300 male smokers (healthy controls) were genotyped. Frequencies were compared by the chi (2) test, and odds ratios (ORs) and their95% confidence intervals (CI) were also calculated. Only the -786 T/C polymorphism in the 5' flanking region of the NOS3 gene was significantly associated with early CAD in our population. The frequency of the CC genotype was significantly increased (P = 0.039) in patients compared to controls (OR = 1.67; 95% CI = 1.01, 2.72). We found a synergistic effect between the NOS3-CC and the ACE-DD genotypes in the risk of developing early CAD. The frequency of CC + DD was significantly increased among patients (P = 0.002). Thus, those with a NOS3-CC and an ACE-DD genotype would have a significantly increased risk of suffering an early episode of coronary artery disease (OR= 2.82; 95% CI = 1.40, 5.70). Although based on a limited number of patients, our work suggests that individuals who are NOS3-CC + ACE-DD are at a higher risk for early CAD, probably as a consequence of increased endothelialdysfunction. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 23:53:34