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Titolo:
Effect of prenatal ethanol exposure during the brain growth spurt of the guinea pig
Autore:
Byrnes, ML; Reynolds, JN; Brien, JF;
Indirizzi:
Queens Univ, Fac Hlth Sci, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6,Canada Queens Univ Kingston ON Canada K7L 3N6 xicol, Kingston, ON K7L 3N6,Canada Queens Univ, Fac Hlth Sci, Dept Anaesthesiol, Kingston, ON K7L 3N6, CanadaQueens Univ Kingston ON Canada K7L 3N6 siol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 4, volume: 23, anno: 2001,
pagine: 355 - 364
SICI:
0892-0362(200107/08)23:4<355:EOPEED>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL-ALCOHOL-SYNDROME; OXIDE SYNTHASE ACTIVITY; NEUROBEHAVIORAL TERATOGENESIS; TEMPORAL VULNERABILITY; LOCOMOTOR-ACTIVITY; HIPPOCAMPUS; ACETALDEHYDE; LIVER; RAT; DEHYDROGENASES;
Keywords:
prenatal ethanol exposure; brain growth spurt; cerebral cortex; hippocampus; cerebellum; spontaneous locomotor activity; guinea pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Brien, JF Queens Univ, Fac Hlth Sci, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6,Canada Queens Univ Kingston ON Canada K7L 3N6 gston, ON K7L 3N6,Canada
Citazione:
M.L. Byrnes et al., "Effect of prenatal ethanol exposure during the brain growth spurt of the guinea pig", NEUROTOX T, 23(4), 2001, pp. 355-364

Abstract

This study tested the hypothesis that prenatal ethanol exposure during thelast third of gestation, including the brain growth spurt (BGS), in the guinea pig produces neurobehavioural teratogenicity, manifesting as brain growth restriction and hyperactivity. Pregnant guinea pigs (term, about gestational day (GD) 68) received oral administration of ethanol (2 g/kg maternalbody weight per day on GD 43 and/or GD 44 and then 4 g/kg maternal body weight per day from GD 45 to GD 62), isocaloric-sucrose/pair-feeding, or water. Maternal blood ethanol concentration (BEC) on GD 57 or 58, at 1 h after the daily dose, was 340 +/- 76 mg/dl (n = 8). Ethanol treatment decreased brain, cerebral cortical, hippocampal, and cerebellar weights at GD 63 (P <0.05), and decreased brain and cerebral cortical weights at postnatal day 10(P <0.05), with no effect on body weight and no apparent effect on spontaneous locomotor activity. The data demonstrate that, in the guinea pig, prenatal ethanol exposure during the last third of gestation, including the BGS, decreases brain weight that persists into postnatal life, which is associated with growth restriction of the cerebral cortex. However, this prenatalethanol exposure regimen, including the BGS, does not increase spontaneouslocomotor activity in contrast to the persistent hyperactivity that occursafter chronic ethanol exposure throughout gestation. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:55:17