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Titolo:
Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants
Autore:
Grandjean, P; Weihe, P; Burse, VW; Needham, LL; Storr-Hansen, E; Heinzow, B; Debes, F; Murata, K; Simonsen, H; Ellefsen, P; Budtz-Jorgensen, E; Keiding, N; White, RF;
Indirizzi:
Univ So Denmark, Inst Publ Hlth, DK-5000 Odense, Denmark Univ So Denmark Odense Denmark DK-5000 ubl Hlth, DK-5000 Odense, Denmark Boston Univ, Sch Med, Dept Environm Hlth, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Dept Environm Hlth, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ, Sch Publ Hlth, Dept Neurol, Boston, MA 02118 USA Boston UnivBoston MA USA 02118 l Hlth, Dept Neurol, Boston, MA 02118 USA Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Dept Environm Hlth, Boston, MA 02118 USA Faroese Hosp Syst, DK-100 Torshavn, Faroe Islands, Denmark Faroese Hosp Syst Torshavn Faroe Islands Denmark DK-100 Islands, Denmark Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA Ctr Dis Control & Prevent Atlanta GA USA 30333 lth, Atlanta, GA 30333 USA Natl Environm Res Inst, DK-4000 Roskilde, Denmark Natl Environm Res Inst Roskilde Denmark DK-4000 K-4000 Roskilde, Denmark State Agcy Nat & Environm Schleswig Holstein, Dept Environm Toxicol, D-24220 Flintbek, Germany State Agcy Nat & Environm Schleswig Holstein Flintbek Germany D-24220 ny Akita Univ, Sch Med, Dept Hyg, Akita 0108543, Japan Akita Univ Akita Japan 0108543 , Sch Med, Dept Hyg, Akita 0108543, Japan Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen S, Denmark Statens Serum Inst Copenhagen Denmark S m, DK-2300 Copenhagen S, Denmark Univ Copenhagen, Dept Biostat, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N stat, DK-2200 Copenhagen N, Denmark Vet Affairs Med Ctr, Environm Hazards Ctr, Boston, MA 02130 USA Vet Affairs Med Ctr Boston MA USA 02130 Hazards Ctr, Boston, MA 02130 USA Vet Affairs Med Ctr, Dept Psychol, Boston, MA 02130 USA Vet Affairs Med Ctr Boston MA USA 02130 ept Psychol, Boston, MA 02130 USA
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 4, volume: 23, anno: 2001,
pagine: 305 - 317
SICI:
0892-0362(200107/08)23:4<305:NDAWPI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCHLORINATED-BIPHENYLS; METHYLMERCURY NEUROTOXICITY; DEVELOPMENTAL EXPOSURE; EVOKED-POTENTIALS; ADIPOSE-TISSUE; HUMAN-MILK; SERUM; DIET; AROCLOR-1254; CONSUMPTION;
Keywords:
methylmercury compounds; neuropsychological tests; polychlorinated biphenyls; prenatal exposure delayed effects; preschool child;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Grandjean, P Univ So Denmark, Inst Publ Hlth, Winslowparken 17, DK-5000 Odense, Denmark Univ So Denmark Winslowparken 17 Odense Denmark DK-5000 mark
Citazione:
P. Grandjean et al., "Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants", NEUROTOX T, 23(4), 2001, pp. 305-317

Abstract

Prenatal exposure to polychlorinated biphenyls (PCBs) was examined by analysis of cord tissue from 435 children from a Faroese birth cohort. Analysisof 50 paired cord blood samples showed excellent correlation with the cordtissue concentration (r=.90). Among 17 neuropsychological outcomes determined at age 7 years, the cord PCB concentration was associated with deficitson the Boston Naming Test (without cues, two-tailed P=.09 not adjusted formercury; with cues, P=.03), the Continuous Performance Test reaction time (P=.03), and, possibly, on long-term recall on the California Verbal Learning Test (P=.15). The association between cord PCB and cord-blood mercury (r=.42) suggested possible confounding. While no PCB effects were apparent inchildren with low mercury exposure, PCB-associated deficits within the highest tertile of mercury exposure indicated a possible interaction between the two neurotoxicants. PCB-associated increased thresholds were seen at twoof eight frequencies on audiometry, but only on the left side, and no deficits occurred on evoked potentials or contrast sensitivity. The limited PCB-related neurotoxicity in this cohort appears to be affected by concomitantmethylmercury exposure. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 03/07/20 alle ore 00:48:01