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Titolo:
Immunohistochemical study on the distribution of voltage-gated K+ channelsin rat brain following transient focal ischemia
Autore:
Chung, YH; Kim, HS; Shin, CM; Kim, MJ; Cha, CI;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Anat, Chongno Gu, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 o Gu, Seoul 110799, South Korea Seoul Natl Univ, Med Res Ctr, Ctr Res Neurosci, Chongno Gu, Seoul 110799, South Korea Seoul Natl Univ Seoul South Korea 110799 o Gu, Seoul 110799, South Korea KNIH, Ctr Biomed Res, Seoul, South Korea KNIH Seoul South KoreaKNIH, Ctr Biomed Res, Seoul, South Korea
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 308, anno: 2001,
pagine: 157 - 160
SICI:
0304-3940(20010810)308:3<157:ISOTDO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOREBRAIN ISCHEMIA; NEURONS; CELLS; CA1;
Keywords:
voltage-gated K+ channels; Kv1.2; focal cerebral ischemia; rat; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Cha, CI Seoul Natl Univ, Coll Med, Dept Anat, Chongno Gu, 28 Yongon Dong, Seoul 110799, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea110799 uth Korea
Citazione:
Y.H. Chung et al., "Immunohistochemical study on the distribution of voltage-gated K+ channelsin rat brain following transient focal ischemia", NEUROSCI L, 308(3), 2001, pp. 157-160

Abstract

The present study examined the spatial localizations of voltage-gated K+ (Kv) channels in the rat brain following transient focal ischemia, using immunohistochemistry. Increased expression of Kv1.2 was obvious in the cerebral cortex, dentate gyrus, amygdala, and hypothalamic areas at 3 days following ischemic insults. There was a significant increase in Kv1.2 immunoreactivity in several cortical regions, including cingulate cortex, infralimbic cortex, dorsal peduncular cortex and piriform cortex. On the contrary, Kv1.2immunoreactivity had not significantly increased in the hippocampal CA1-3 regions although moderate Kv1.2 immunoreactivity was found in the cell bodies and processes of some neurons. Potentially the first demonstration of spatial changes in Kv1.2 channel expression could provide important molecularbasis for altered neuronal excitability after ischemic brain injury. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:10:45