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Titolo:
Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
Autore:
Gowan, K; Helms, AW; Hunsaker, TL; Collisson, T; Ebert, PJ; Odom, R; Johnson, JE;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 , Ctr Basic Neurosci, Dallas, TX 75390 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 31, anno: 2001,
pagine: 219 - 232
SICI:
0896-6273(20010802)31:2<219:CAONAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE NEURONS; PERIPHERAL NERVOUS-SYSTEM; PROGENITOR-CELL IDENTITY; ACHAETE-SCUTE HOMOLOG-1; SPINAL-CORD; COMMISSURAL INTERNEURONS; DETERMINATION GENES; PRONEURAL GENES; BHLH GENES; ROOF PLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, JE Univ Texas, SW Med Ctr, Ctr Basic Neurosci, 5323 Harry Hines Blvd, Dallas,TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
K. Gowan et al., "Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons", NEURON, 31(2), 2001, pp. 219-232

Abstract

Distinct classes of neurons are generated from progenitor cells distributed in characteristic dorsoventral patterns in the developing spinal neural tube. We define restricted neural progenitor populations by the discrete, nonoverlapping expression of Ngn1, Math1, and Mash1. Crossinhibition between these bHLH factors is demonstrated and provides a mechanism for the generation of discrete bHLH expression domains. This precise control of bHLH factor expression is essential for proper neural development since as demonstrated in both loss- and gain-of-function experiments, expression of Math1 or Ngn1 in dorsal progenitor cells determines whether LH2A/B- or dorsal Lim1/2-expressing interneurons will develop. Together, the data suggest that although Math1 and Ngn1 appear to be redundant with respect to neurogenesis, they have distinct functions in specifying neuronal subtype in the dorsal neural tube.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:40:10