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Titolo:
Alzheimer's disease and AP toxicity: from top to bottom
Autore:
Small, DH; Mok, SS; Bornstein, JC;
Indirizzi:
Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 8, volume: 2, anno: 2001,
pagine: 595 - 598
SICI:
1471-0048(200108)2:8<595:ADAATF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-BETA-PROTEIN; NF-KAPPA-B; CORTICAL-NEURONS; HIPPOCAMPAL-NEURONS; SCAVENGER RECEPTOR; MEMORY MAINTENANCE; PRECURSOR PROTEIN; MICROGLIAL CELLS; NEURAL NETWORKS; C-JUN;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Small, DH Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia UnivMelbourne Melbourne Vic Australia 3010 Vic 3010, Australia
Citazione:
D.H. Small et al., "Alzheimer's disease and AP toxicity: from top to bottom", NAT REV NEU, 2(8), 2001, pp. 595-598

Abstract

Evidence implicating the beta -amyloid protein (A beta) in the pathogenesis of Alzheimer's disease has steadily accumulated. However, the mechanism by which A beta causes dementia is unknown, Here we argue that a more integrated, top-down approach to brain function is needed to assess the role of Abeta in Alzheimer's disease, and that more attention should be paid to theeffects of A beta on synaptic function rather than on cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:43:06