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Titolo:
Failure of the ubiquitin-proteasome system in Parkinson's disease
Autore:
McNaught, KSP; Olanow, CW; Halliwell, B; Isacson, O; Jenner, P;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 eurol, New York, NY 10029 USA Harvard Univ, Sch Med, Neuroregenerat Lab, Belmont, MA 02478 USA Harvard Univ Belmont MA USA 02478 uroregenerat Lab, Belmont, MA 02478 USA McLean Hosp, Belmont, MA 02478 USA McLean Hosp Belmont MA USA 02478McLean Hosp, Belmont, MA 02478 USA Natl Univ Singapore, Dept Biochem, Singapore 0511, Singapore Natl Univ Singapore Singapore Singapore 0511 , Singapore 0511, Singapore Univ London Kings Coll, GKT Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 8, volume: 2, anno: 2001,
pagine: 589 - 594
SICI:
1471-0048(200108)2:8<589:FOTUSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE JUVENILE PARKINSONISM; CARBOXY-TERMINAL HYDROLASE; ALPHA-SYNUCLEIN; NEURODEGENERATIVE DISEASES; LEWY-BODY; PROTEIN AGGREGATION; INCLUSION-BODIES; GENE; MUTATION; ASSOCIATION;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: McNaught, KSP CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 k, NY 10029 USA
Citazione:
K.S.P. McNaught et al., "Failure of the ubiquitin-proteasome system in Parkinson's disease", NAT REV NEU, 2(8), 2001, pp. 589-594

Abstract

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by degeneration of dopamine-containing neurons in the midbrain. In cases of familial PD, mutations that lead to failure of the ubiquitin-proteasome system (UPS) have been identified. These genetic abnormalities do not occur in sporadic PD, but we propose that impairment of the UPS could also contribute to neurodegeneration in this disorder, We discuss evidence that failure of the UPS is a common aetiopathogenic factor that underlies the development of familial and sporadic PD, an idea that might help to explain clinical and pathological differences and similarities in these disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:12:18