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Titolo:
Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies
Autore:
Bezard, E; Brotchie, JM; Gross, CE;
Indirizzi:
Univ Victor Segalen Bordeaux 2, CNRS, UMR 5543, Neurophysiol Lab, F-33076 Bordeaux, France Univ Victor Segalen Bordeaux 2 Bordeaux France F-33076 Bordeaux, France Motac Neurosci Ltd, Manchester M13 9XX, Lancs, England Motac Neurosci LtdManchester Lancs England M13 9XX 3 9XX, Lancs, England Univ Manchester, Sch Biol Sci, Manchester Movement Disorder Lab, Div Neurosci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 8, volume: 2, anno: 2001,
pagine: 577 - 588
SICI:
1471-0048(200108)2:8<577:POLDPF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DOPA-INDUCED DYSKINESIAS; PARKINSONS-DISEASE PATIENTS; AGONIST-INDUCED DYSKINESIA; MPTP-INDUCED PARKINSONISM; D-3 RECEPTOR EXPRESSION; GLOBUS-PALLIDUS NEURONS; MESSENGER-RNA LEVELS; BASAL GANGLIA; STRIATAL NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Gross, CE Univ Victor Segalen Bordeaux 2, CNRS, UMR 5543, Neurophysiol Lab, 146 Rue Leo Saignat, F-33076 Bordeaux, France Univ Victor Segalen Bordeaux 2 146 Rue Leo Saignat Bordeaux France F-33076
Citazione:
E. Bezard et al., "Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies", NAT REV NEU, 2(8), 2001, pp. 577-588

Abstract

Involuntary movements - or dyskinesias - are a debilitating complication of levodopa therapy for Parkinson's disease, and is experienced in most patients. Despite the importance of this problem, little was known about the cause of dyskinesia until recently; however, this situation has changed significantly in the past few years. Our increased understanding of levodopa-induced dyskinesia is not only valuable for improving patient care, but also in providing us with new insights into the functional organization of the basal ganglia and motor systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:04:01