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Titolo:
Determining centromere identity: Cyclical stories and forking paths
Autore:
Sullivan, BA; Blower, MD; Karpen, GH;
Indirizzi:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92037 USA Univ Calif San Diego La Jolla CA USA 92037 t Biol, La Jolla, CA 92037 USA
Titolo Testata:
NATURE REVIEWS GENETICS
fascicolo: 8, volume: 2, anno: 2001,
pagine: 584 - 596
SICI:
1471-0056(200108)2:8<584:DCICSA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-SATELLITE DNA; HISTONE FOLD DOMAIN; PROTEIN CENP-A; FISSION YEAST; SCHIZOSACCHAROMYCES-POMBE; SACCHAROMYCES-CEREVISIAE; CHROMOSOME SEGREGATION; ARTIFICIAL CHROMOSOMES; FUNCTIONAL CENTROMERES; ARABIDOPSIS-THALIANA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Karpen, GH Salk Inst Biol Studies, Mol & Cell Biol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
B.A. Sullivan et al., "Determining centromere identity: Cyclical stories and forking paths", NAT REV GEN, 2(8), 2001, pp. 584-596

Abstract

The centromere is the genetic locus required for chromosome segregation. It is the site of spindle attachment to the chromosomes and is crucial for the transfer of genetic information between cell and organismal generations. Although the centromere was first recognized more than 120 years ago, little is known about what determines its site(s) of activity, and how it contributes to kinetochore formation and spindle attachment. Recent work in thisfield has supported the hypothesis that most eukaryotic centromeres are determined epigenetically rather than by primary DNA sequence. Here, we review recent studies that have elucidated the organization and functions of centromeric chromatin, and evaluate present-day models for how centromere identity and propagation are determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:17:15