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Titolo:
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
Autore:
Perlman, R; Schiemann, WP; Brooks, MW; Lodish, HF; Weinberg, RA;
Indirizzi:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 8, volume: 3, anno: 2001,
pagine: 708 - 714
SICI:
1465-7392(200108)3:8<708:TAIMBT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; TERMINAL KINASE SAPK/JNK; HEPATOCYTE CELL-LINES; SIGNAL-TRANSDUCTION; TRANSFORMING GROWTH-FACTOR-BETA-1; INTERACTING PROTEIN; RECEPTOR COMPLEX; DOMAIN PROTEIN; B-CELLS; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberg, RA Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA USA 02142
Citazione:
R. Perlman et al., "TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation", NAT CELL BI, 3(8), 2001, pp. 708-714

Abstract

Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that has a principal role in growth control through both its cytostaticeffect on many different epithelial cell types and its ability to induce programmed cell death in a variety of other cell types. Here we have used a screen for proteins that interact physically with the cytoplasmic domain ofthe type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and programmed cell death induced by Fas. The carboxy-terminal portion of Daxx functions as a dominant-negative inhibitor of TGF-beta -induced apoptosis in B-cell lymphomas, and antisense oligonucleotides to Daxx inhibit TGF-beta -induced apoptosis in mouse hepatocytes. Furthermore, Daxx is involved in mediating JNK activation by TGF-beta. Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, andmake a biochemical connection between the receptors for TGF-beta and the apoptotic machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:44:18