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Titolo:
The importance of using absolute mutant frequencies to compare mutation spectra
Autore:
Kuipers, GK; Slotman, BJ; Lafleur, MVM;
Indirizzi:
Free Univ Amsterdam, Med Ctr, Fac Med, Dept Radiat Oncol,Sect Radiobiol, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 BT terdam, Netherlands
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 479, anno: 2001,
pagine: 95 - 99
SICI:
1386-1964(20010808)479:1-2<95:TIOUAM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE EXCISION-REPAIR; LACZ-ALPHA GENE; RADIATION-INDUCED MUTATIONS; STRANDED M13 DNA; GAMMA-RADIATION; ESCHERICHIA-COLI; SEQUENCE-ANALYSIS; SPECIFICITY; IRRADIATION; MUTAGENESIS;
Keywords:
mutation spectrum; absolute mutant frequency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kuipers, GK Free Univ Amsterdam, Med Ctr, Fac Med, Dept Radiat Oncol,Sect Radiobiol, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
G.K. Kuipers et al., "The importance of using absolute mutant frequencies to compare mutation spectra", MUT RES-F M, 479(1-2), 2001, pp. 95-99

Abstract

Because damage to the cellular DNA is very hazardous for a cell, it is important to identify compounds, which can cause DNA damage. To investigate the mutagenic effect of a particular agent of interest, usually mutation spectra are determined in a selected target gene. The most commonly used methodto compare different mutation spectra with each other, is the comparison of the percentages of each type of mutation. In this paper, it is emphasizedthat comparison of percentages can lead to incorrect conclusions and therefore another determinant, the absolute mutant frequency, should be used. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:20:22