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Titolo:
Corticobasal syndrome with tau pathology
Autore:
Cordato, NJ; Halliday, GM; McCann, H; Davies, L; Williamson, P; Fulham, M; Morris, JGL;
Indirizzi:
Prince Wales Med Res Inst, Randwick, NSW 2031, Australia Prince Wales Med Res Inst Randwick NSW Australia 2031 NSW 2031, Australia Westmead Hosp, Dept Neurol, Westmead, NSW 2145, Australia Westmead Hosp Westmead NSW Australia 2145 , Westmead, NSW 2145, Australia Royal Prince Alfred Hosp, Dept Neurol, Camperdown, NSW, Australia Royal Prince Alfred Hosp Camperdown NSW Australia erdown, NSW, Australia Royal N Shore Hosp, Dept Neurol, St Leonards, NSW 2065, Australia Royal N Shore Hosp St Leonards NSW Australia 2065 ds, NSW 2065, Australia Royal Prince Alfred Hosp, Dept PET & Nucl Med, Camperdown, NSW, Australia Royal Prince Alfred Hosp Camperdown NSW Australia erdown, NSW, Australia
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 4, volume: 16, anno: 2001,
pagine: 656 - 667
SICI:
0885-3185(200107)16:4<656:CSWTP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; BASAL GANGLIONIC DEGENERATION; RICHARDSON-OLSZEWSKI-SYNDROME; REGIONAL BRAIN ATROPHY; CEREBRAL BLOOD-FLOW; LEWY BODY DISEASE; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; FLUORODOPA UPTAKE; INTERNATIONAL WORKSHOP;
Keywords:
brain atrophy; corticobasal degeneration; neuropathology; precentral gyrus; progressive supranuclear palsy; tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Cordato, NJ Prince Wales Med Res Inst, High St, Randwick, NSW 2031, Australia Prince Wales Med Res Inst High St Randwick NSW Australia 2031
Citazione:
N.J. Cordato et al., "Corticobasal syndrome with tau pathology", MOVEMENT D, 16(4), 2001, pp. 656-667

Abstract

Six cases with a clinical corticobasal syndrome (progressive asymmetric apraxia and parkinsonism unresponsive to levodopa) and tau pathology were selected from 97 brain donors with parkinsonism. Postmortem volumetric measures of regional brain atrophy (compared with age/sex-matched controls) were correlated with clinical features and the degree of underlying cortical and subcortical histopathology. At death, no significant asymmetry of pathologywas detected. All cases had prominent bilateral atrophy of the precentral gyrus (reduced by 22-54%) with other cortical regions variably affected. Subcortical atrophy was less severe and variable. Two cases demonstrated widespread atrophy of basal ganglia structures (44-60% atrophy of the internal globus pallidus) and substantial subcortical pathology consistent with a diagnosis of progressive supranuclear palsy (PSP). The remaining four cases had typical pathology of corticobasal degeneration. In all cases, neuronal loss and gliosis corresponded with subcortical atrophy, while the density ofcortical swollen neurons correlated with cortical volume loss. Atrophy of the internal globus pallidus was associated with postural instability, while widespread basal ganglia histopathology was found in cases with gaze palsy. This study confirms the involvement of the precentral gyrus in the corticobasal syndrome and highlights the variable underlying pathology in these patients. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:15:07