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Titolo:
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal
Autore:
Akbarian, S; Bates, B; Liu, RJ; Skirboll, SL; Pejchal, T; Coppola, V; Sun, LD; Fan, G; Kucera, J; Wilson, MA; Tessarollo, L; Kosofsky, BE; Taylor, JR; Bothwell, M; Nestler, EJ; Aghajanian, GK; Jaenisch, R;
Indirizzi:
Whitehead Inst, Cambridge, MA 02142 USA Whitehead Inst Cambridge MA USA 02142 ehead Inst, Cambridge, MA 02142 USA Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Neurol, Boston, MA 02114 USA Yale Univ, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA NCI, Frederick, MD 21701 USA NCI Frederick MD USA 21701NCI, Frederick, MD 21701 USA MIT, Dept Biol, Cambridge, MA USA MIT Cambridge MA USAMIT, Dept Biol, Cambridge, MA USA Boston Univ, Dept Neurol, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 n Univ, Dept Neurol, Boston, MA 02215 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 5, volume: 6, anno: 2001,
pagine: 593 - 604
SICI:
1359-4184(200109)6:5<593:NMNNFA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; LOCUS-COERULEUS; RAT-BRAIN; ANTEROGRADE TRANSPORT; TRANSGENIC MICE; NERVOUS-SYSTEM; PROTEIN-KINASE; NT-3; CERULEUS; TRKC;
Keywords:
locus coeruleus; morphine; addiction; norepinephrine; cre recombinase; pons; medulla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Jaenisch, R Whitehead Inst, 9 Cambridge Ctr, Cambridge, MA 02142 USA Whitehead Inst 9 Cambridge Ctr Cambridge MA USA 02142 2142 USA
Citazione:
S. Akbarian et al., "Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal", MOL PSYCHI, 6(5), 2001, pp. 593-604

Abstract

Somatic symptoms and aversion of opiate withdrawal, regulated by noradrenergic signaling, were attenuated in mice with a CNS-wide conditional ablation of neurotrophin-3. This occurred in conjunction with altered cAMP-mediated excitation and reduced upregulation of tyrosine hydroxylase in A6 (locus coeruleus) without loss of neurons. Transgene-derived NT-3 expressed by noradrenergic neurons of conditional mutants restored opiate withdrawal symptoms. Endogenous NT-3 expression, strikingly absent in noradrenergic neurons of postnatal and adult brain, is present in afferent sources of the dorsal medulla and is upregulated after chronic morphine exposure in noradrenergicprojection areas of the ventral forebrain. NT-3 expressed by noncatecholaminergic neurons may modulate opiate withdrawal and noradrenergic signalling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:28:17