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Titolo:
St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term andlong-term administration in normal and stressed rats
Autore:
Butterweck, V; Winterhoff, H; Herkenham, M;
Indirizzi:
NIMH, Funct Neuroanat Sect, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 , Funct Neuroanat Sect, Bethesda, MD 20892 USA Inst Pharmacol & Toxicol, D-48149 Munster, Germany Inst Pharmacol & Toxicol Munster Germany D-48149 -48149 Munster, Germany
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 5, volume: 6, anno: 2001,
pagine: 547 - 564
SICI:
1359-4184(200109)6:5<547:SJWHAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; MESSENGER-RNA EXPRESSION; PITUITARY-ADRENOCORTICAL AXIS; GAMMA-AMINOBUTYRIC-ACID; FORCED SWIMMING TEST; TYROSINE-HYDROXYLASE; ANTIDEPRESSANT ACTIVITY; PARAVENTRICULAR NUCLEUS; ARGININE-VASOPRESSIN; MINERALOCORTICOID RECEPTOR;
Keywords:
antidepressant; hypothalamic-pituitary-adrenal; corticotropin-releasing hormone; paraventricular hypothalamic nucleus; norepinephrine; locus coeruleus; imipramine; Hypericum; in situ hybridization; gene expression regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Herkenham, M NIMH, Funct Neuroanat Sect, NIMH Bldg 36,Rm 2D-15, Bethesda, MD 20892 USA NIMH NIMH Bldg 36,Rm 2D-15 Bethesda MD USA 20892 MD 20892 USA
Citazione:
V. Butterweck et al., "St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term andlong-term administration in normal and stressed rats", MOL PSYCHI, 6(5), 2001, pp. 547-564

Abstract

Clinical studies demonstrate that the antidepressant efficacy of St John'swort (Hypericum) is comparable to that of tricyclic antidepressants such as imipramine. Onset of efficacy of these drugs occurs after several weeks of treatment. Therefore, we used in situ hybridization histochemistry to examine in rats the effects of short-term (2 weeks) and long-term (8 weeks) administration of imipramine, Hypericum extract, and hypericin (an active constituent of St John's wort) on the expression of genes that may be involvedin the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Imipramine (15 mg kg(-1)), Hypericum (500 mg kg(-1)), and hypericin (0.2 mg kg(-1)) given daily by gavage for 8 weeks but not for 2 weeks significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 16-22% in thehypothalamic paraventricular nucleus (PVN) and serotonin 5-HT1A receptor mRNA by 11-17% in the hippocampus. Only imipramine decreased tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (by 23%), and only at 8 weeks. The similar delayed effects of the three compounds on gene transcription suggests a shared action on the centers that control HPA axis activity. A second study was performed to assess the effects of long-term imipramine andHypericum administration on stress-induced changes in gene transcription in stress-responsive circuits. Repeated immobilization stress (2 h daily for7 days) increased mRNA levels of CRH in the PVN, proopiomelanocortin (POMC) in the anterior pituitary, glutamic acid decarboxylase (GAD 65/67) in thebed nucleus of the stria terminalis (BST), cyclic AMP response element binding protein (CREB) in the hippocampus, and TH in the locus coeruleus. It decreased mRNA levels of 5-HT1A and brain-derived neurotrophic factor (BDNF)in the hippocampus. Long-term pretreatment with either imipramine or Hypericum reduced to control levels the stress-induced increases in gene transcription of GAD in the BST, CREB in the hippocampus, and POMC in the pituitary. The stress-induced increases in mRNA levels of CRH in the PVN and TH in the locus coeruleus were reduced by imipramine but not by Hypericum. The stress-induced decreases in BDNF and 5-HT1A mRNA levels were not prevented byeither drug. Taken together, these data show: (1) that Hypericum and hypericin have delayed effects on HPA axis control centers similar to those of imipramine; and (2) that select stress-induced changes in gene transcriptionin particular brain areas can be prevented by long-term treatment with either the prototypic tricyclic antidepressant imipramine or the herbiceuticalSt John's wort. However, imipramine appears to be more effective in blocking stress effects on the HPA axis than the plant extract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/12/18 alle ore 00:30:03