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Titolo:
Expression of corticotropin releasing hormone receptors type I and type IImRNA in suicide victims and controls
Autore:
Hiroi, N; Wong, ML; Licinio, J; Park, C; Young, M; Gold, PW; Chrousos, GP; Bornstein, SR;
Indirizzi:
MNR Univ Dusseldorf, Dept Endocrinol, D-40001 Dusseldorf, Germany MNR UnivDusseldorf Dusseldorf Germany D-40001 40001 Dusseldorf, Germany NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 docrinol Branch, NIH, Bethesda, MD 20892 USA NIMH, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, NIH, Bethesda, MD 20892 USA Univ Calif Los Angeles, Sch Med, Inst Neuropsychiat, Lab Pharmacogenom, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Dusseldorf, Dept Endocrinol, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ol, D-4000 Dusseldorf, Germany
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 5, volume: 6, anno: 2001,
pagine: 540 - 546
SICI:
1359-4184(200109)6:5<540:EOCRHR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED STRESS-RESPONSE; MAJOR DEPRESSION; MESSENGER-RNA; MICE LACKING; FACTOR CRF; RAT-BRAIN; ANTAGONIST; LOCALIZATION; CLONING; HORMONE-RECEPTOR-1;
Keywords:
CRH receptor; human tissues; pituitary; suicide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Bornstein, SR MNR Univ Dusseldorf, Dept Endocrinol, Mooren Str 5, D-40001 Dusseldorf, Germany MNR Univ Dusseldorf Mooren Str 5 Dusseldorf Germany D-40001
Citazione:
N. Hiroi et al., "Expression of corticotropin releasing hormone receptors type I and type IImRNA in suicide victims and controls", MOL PSYCHI, 6(5), 2001, pp. 540-546

Abstract

Corticotropin-releasing hormone (CRH) is a key neuroendocrine factor implementing endocrine, immune and behavioral responses to stress. CRH exerts its action through two major receptors, CRH-R1 and CRH-R2. Recently novel non-peptidic antagonists directed against CRH-R1 or CRH-R2 have been proposed as promising agents in the treatment of depression, anxiety and eating disorder. However, so far the CRH-receptor system has not been widely studied in humans. Therefore, we employed quantitative TaqMan PCR to analyze the expression and distribution of both CRH-R1 and CRH-R2 in human brain tissue and peripheral organs. Furthermore the expression of CRH receptors was analyzed for the first time in pituitaries of suicide victims by in situ hybridization and quantitative PCR. Our data demonstrated a different expression pattern in humans as compared to rodents. Both CRH-R1 and CRH-R2 were expressed in high amounts in the brain with the strongest expression in the pituitary. As described in rodents, however the CRH-R1 in human was the predominant receptor in the brain (82.7 +/- 11.0%), whilst CRH-R2 was the predominant receptor in peripheral organs (77.0 +/- 15.8%). There was a shift in the ratio of CRH-R1/R2 in the pituitaries of suicide victims. In conclusion, both CRH-R1 and GRH-R2 are widely expressed in human tissues with a distribution substantially different from rodents. Strong expression of both CRH-R1 and CRH-R2 in human pituitaries suggests that particularly under stress, activation of the HPA axis can be maintained through both receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:19:37