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Titolo:
Genetic mechanisms of behavior - Don't forget about the transcription factors
Autore:
Damberg, M; Garpenstrand, H; Hallman, J; Oreland, L;
Indirizzi:
Uppsala Univ, Dept Neurosci, Pharmacol Unit, SE-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75124 acol Unit, SE-75124 Uppsala, Sweden Uppsala Univ, Dept Neurosci, Unit Psychiat, Uppsala, Sweden Uppsala Univ Uppsala Sweden pt Neurosci, Unit Psychiat, Uppsala, Sweden
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 5, volume: 6, anno: 2001,
pagine: 503 - 510
SICI:
1359-4184(200109)6:5<503:GMOB-D>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE ACTIVITY; PLATELET MAO ACTIVITY; DOPAMINE-BETA-HYDROXYLASE; SEROTONIN TRANSPORTER GENE; CEREBROSPINAL-FLUID; FACTOR AP-2-BETA; MESSENGER-RNA; FACTOR AP-2; MOUSE EMBRYOGENESIS; PERSONALITY-TRAITS;
Keywords:
monoamine oxidase; AP-2; transcription; thrombocyte; serotonin; antidepressant; binge eating; personality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Oreland, L Uppsala Univ, Dept Neurosci, Pharmacol Unit, SE-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75124 SE-75124 Uppsala, Sweden
Citazione:
M. Damberg et al., "Genetic mechanisms of behavior - Don't forget about the transcription factors", MOL PSYCHI, 6(5), 2001, pp. 503-510

Abstract

Major changes in psychiatric phenotypes due to genetic factors are seldom the result of single gene polymorphisms, but more often the result of several genetic mechanisms. In this millennium article we discuss the notion that the expression of numerous candidate genes could be regulated by the sametranscription factors, and that polymorphisms in transcription factor genes might explain some phenotypes. We describe recent results of studies on the biological marker thrombocyte monoamine oxidase (trbc MAO) and the transcription factor AP-2 beta. Low levels of trbc MAO is associated with temperamental characteristics such as sensation seeking and impulsiveness, and the enzyme is genetically regulated by specific transcriptional mechanisms. Transcription factor AP-2 beta is important for the development of midbrain structures and AP-2 beta has several binding sites in the regulatory regions of genes encoding key proteins in the monoamine transmitter systems. We have recently shown AP-2 beta to be linked to personality, binge-eating disorder, treatment with antidepressant drugs, and also to trbc MAO. Regardlessof whether transcriptions factors, such as AP-2 beta, regulate the expression of eg, the number of monoamine neurons or a variety of candidate genes within the monoamine systems, or both, we would like to emphasize the role of transcription factors, besides polymorphisms in monoaminergic candidate genes, when explaining inter-individual differences in temperament and psychiatric vulnerability.

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Documento generato il 03/04/20 alle ore 20:29:38