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Titolo:
Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure
Autore:
Cocco, RE; Ucker, DS;
Indirizzi:
Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 obiol & Immunol, Chicago, IL 60612 USA
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 4, volume: 12, anno: 2001,
pagine: 919 - 930
SICI:
1059-1524(200104)12:4<919:DMOMRF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; RED-BLOOD-CELLS; VITRONECTIN RECEPTOR; SCAVENGER RECEPTOR; INFLAMMATORY MACROPHAGES; DENDRITIC CELLS; T-LYMPHOCYTES; NULL MUTATION; IN-VITRO; PHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Ucker, DS Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 munol, Chicago, IL 60612 USA
Citazione:
R.E. Cocco e D.S. Ucker, "Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure", MOL BIOL CE, 12(4), 2001, pp. 919-930

Abstract

The distinction between physiological (apoptotic) and pathological (necrotic) cell deaths reflects mechanistic differences in cellular disintegrationand is of functional significance with respect to the outcomes that are triggered by the cell corpses. Mechanistically, apoptotic cells die via an active and ordered pathway; necrotic deaths, conversely, are chaotic and passive. Macrophages and other phagocytic cells recognize and engulf these deadcells. This clearance is believed to reveal an innate immunity, associatedwith inflammation in cases of pathological but not physiological cell deaths. Using objective and quantitative measures to assess these processes, wefind that macrophages bind and engulf native apoptotic and necrotic cells to similar extents and with similar kinetics. However, recognition of thesetwo classes of dying cells occurs via distinct and noncompeting mechanisms. Phosphatidylserine, which is externalized on both apoptotic and necrotic cells, is not a specific ligand for the recognition of either one. The distinct modes of recognition for these different corpses are linked to opposing responses from engulfing macrophages. Necrotic cells, when recognized, enhance proinflammatory responses of activated macrophages, although they arenot sufficient to trigger macrophage activation. In marked contrast, apoptotic cells profoundly inhibit phlogistic macrophage responses; this represents a cell-associated, dominant-acting anti-inflammatory signaling activityacquired posttranslationally during the process of physiological cell death.

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Documento generato il 23/09/20 alle ore 05:39:43