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Titolo:
Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction
Autore:
Tanaka, M; Miyoshi, J; Ishizaki, H; Togawa, A; Ohnishi, K; Endo, K; Matsubara, K; Mizoguchi, A; Nagano, T; Sato, M; Sasaki, T; Takai, Y;
Indirizzi:
Osaka Univ, Fac Med, Grad Sch Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Biochem, Suita, Osaka 5650871, Japan JCR Pharmaceut Co Ltd, Japan Sci & Technol Corp, ERATO, Takai Biotimer Project, Kobe, Hyogo 6512241, Japan JCR Pharmaceut Co Ltd Kobe Hyogo Japan 6512241 Kobe, Hyogo 6512241, Japan Kyoto Univ, Fac Med, Grad Sch Med, Dept Physiol, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 h Med, Dept Physiol, Kyoto 6068501, Japan Kyoto Univ, Fac Med, Grad Sch Med, Dept Anat & Neurobiol, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 pt Anat & Neurobiol, Kyoto 6068501, Japan Fukui Med Univ, Fac Med, Dept Anat 2, Fukui 9101193, Japan Fukui Med UnivFukui Japan 9101193 ed, Dept Anat 2, Fukui 9101193, Japan
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 5, volume: 12, anno: 2001,
pagine: 1421 - 1430
SICI:
1059-1524(200105)12:5<1421:RORGEP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING PROTEIN; CA2+-DEPENDENT EXOCYTOSIS; SECRETORY GRANULES; LOCALIZATION; MEMBRANE; CELLS; DISSOCIATION; ENDOCYTOSIS; EXPRESSION; TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Takai, Y Osaka Univ, Fac Med, Grad Sch Med, Dept Mol Biol & Biochem, 2-2 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
M. Tanaka et al., "Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction", MOL BIOL CE, 12(5), 2001, pp. 1421-1430

Abstract

The Rab3 small G protein family consists of four members, Rab3A, -3B, -3C,and -3D. Of these members, Rab3A regulates Ca2(+)-dependent neurotransmitter release. These small G proteins axe activated by Rab3 GDP/GTP exchange protein (Rab3 GEP). To determine the function of Rab3 GEP during neurotransmitter release, we have knocked out Rab3 GEP in mice. Rab3 GEP -/- mice developed normally but died immediately after birth. Embryos at E18.5 showed noevoked action potentials of the diaphragm and gastrocnemius muscles in response to electrical stimulation of the phrenic and sciatic nerves, respectively. In contrast, axonal conduction of the spinal cord and the phrenic nerve was not impaired. Total numbers of synaptic vesicles, especially those docked at the presynaptic plasma membrane, were reduced at the neuromuscularjunction similar to 10-fold compared with controls, whereas postsynaptic structures and functions appeared normal. Thus, Rab3 GEP is essential for neurotransmitter release and probably for formation and trafficking of the synaptic vesicles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:45:15