Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence for the role of MAP1B in axon formation
Autore:
Gonzalez-Billault, C; Avila, J; Caceres, A;
Indirizzi:
Univ Autonoma Madrid, CSIC, Ctr Mol Biol, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 ol Biol, E-28049 Madrid, Spain Consejo Nacl Invest Cient & Tecn, INIMEC, Inst Invest Med Mercedes & Martin Ferreyra, Cordoba, Argentina Consejo Nacl Invest Cient & Tecn Cordoba Argentina , Cordoba, Argentina
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 7, volume: 12, anno: 2001,
pagine: 2087 - 2098
SICI:
1059-1524(200107)12:7<2087:EFTROM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE-ASSOCIATED PROTEINS; GROWTH CONES; CEREBELLAR MACRONEURONS; HIPPOCAMPAL-NEURONS; NEURITE OUTGROWTH; DEVELOP INVITRO; GROWING AXONS; TAU-PROTEIN; EXPRESSION; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Caceres, A Univ Autonoma Madrid, CSIC, Ctr Mol Biol, E-28049 Madrid, SpainUniv Autonoma Madrid Madrid Spain E-28049 28049 Madrid, Spain
Citazione:
C. Gonzalez-Billault et al., "Evidence for the role of MAP1B in axon formation", MOL BIOL CE, 12(7), 2001, pp. 2087-2098

Abstract

Cultured neurons obtained from a hypomorphous MAP1B mutant mouse line display a selective and significant inhibition of axon formation that reflects a delay in axon outgrowth and a reduced rate of elongation. This phenomenonis paralleled by decreased microtubule formation and dynamics, which is dramatic at the distal axonal segment, as well as in growth cones, where the more recently assembled microtubule polymer normally predominates. These neurons also have aberrant growth cone formation and increased actin-based protrusive activity. Taken together, this study provides direct evidence showing that by promoting microtubule dynamics and regulating cytoskeletal organization MAP1B has a crucial role in axon formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:19:54