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Titolo:
Phenotype of cytochrome P450CYP2D6 in patients with familial adenomatous polyposis
Autore:
Slanar, O; Perlik, F; Jirasek, V;
Indirizzi:
Charles Univ, Fac Med 1, Gen Teaching Hosp, Dept Med 1,Clin Pharmacol Unit, Prague, Czech Republic Charles Univ Prague Czech Republic armacol Unit, Prague, Czech Republic Inst Postgrad Med Educ, Dept Clin Pharmacol, Prague, Czech Republic Inst Postgrad Med Educ Prague Czech Republic ol, Prague, Czech Republic
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 145 - 147
SICI:
0379-0355(200104)23:3<145:POCPIP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYP2D6 GENE POLYMORPHISM; LUNG-CANCER PATIENTS; BLADDER-CANCER; DEBRISOQUINE; OXIDATION; RISK; SPARTEINE; PREDISPOSITION; SUSCEPTIBILITY; ACETYLATION;
Keywords:
CYP2D6; cytochrome P450; familial adenomatous polyposis; sparteine; phenotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Slanar, O Dept Med 1, Clin Pharmacol Unit, U Nemocnice 2, CZ-12808 Prague 2, Czech Republic Dept Med 1 U Nemocnice 2 Prague Czech Republic 2 Czech Republic
Citazione:
O. Slanar et al., "Phenotype of cytochrome P450CYP2D6 in patients with familial adenomatous polyposis", METH FIND E, 23(3), 2001, pp. 145-147

Abstract

This paper describes an attempt to establish the distribution of the oxidative phenotype of sparteine in patients with familial adenomatous polyposis(FAP). The oxidative polymorphism of sparteine was determined in 30 patients with FAR One hundred and twenty-six normal subjects were examined as a control group. Subjects with urinary metabolic ratios (AIR) greater than 20 (the metabolic ratio of sparteine/dehydrosparteines excreted in urine) weredefined as poor metabolizers of sparteine. None of the patients were classified as poor metabolizers of sparteine, although 5 control subjects were. No significant differences were found in the distribution of frequencies between patients arid control subjects. However, there was a higher metabolicratio (mean 1.58 +/- 1.13) in 5 patients with malignant changes in large bowel adenomas compared with other FAP patients without malignant changes (mean MR 0.89 +/- 0.66). (C) 2001 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:41:12