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Titolo:
Dietary supplementation of the pyridoindole antioxidant stobadine reduces vascular impairment in streptozotocin-diabetic rats
Autore:
Sotnikova, R; Stefek, L; Okruhlicova, L; Navarova, J; Bauer, V; Gajdosik, A; Gajdosikova, A;
Indirizzi:
Slovak Acad Sci, Inst Expt Pharmacol, Bratislava 84216, Slovakia Slovak Acad Sci Bratislava Slovakia 84216 ol, Bratislava 84216, Slovakia Slovak Acad Sci, Heart Res Inst, Bratislava 84216, Slovakia Slovak Acad Sci Bratislava Slovakia 84216 st, Bratislava 84216, Slovakia
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 121 - 129
SICI:
0379-0355(200104)23:3<121:DSOTPA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ENDOTHELIAL DYSFUNCTION; FREE-RADICALS; VITAMIN-E; CARDIOPROTECTIVE AGENT; OXIDATIVE STRESS; NITRIC-OXIDE; MELLITUS; AORTA; CONTRACTION; PREVENTION;
Keywords:
antioxidants; diabetes; streptozotocin; stobadine; ultrastructure; vascular reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sotnikova, R Slovak Acad Sci, Inst Expt Pharmacol, Dubravska Cesta 9, Bratislava 84216,Slovakia Slovak Acad Sci Dubravska Cesta 9 Bratislava Slovakia 84216
Citazione:
R. Sotnikova et al., "Dietary supplementation of the pyridoindole antioxidant stobadine reduces vascular impairment in streptozotocin-diabetic rats", METH FIND E, 23(3), 2001, pp. 121-129

Abstract

We studied the influence of hyperglycemia lasting 1, 4, 6 and 8 months on the reactivity and ultrastructure of the aorta in Wistar rats. Moreover, the effect of the pyridoindole antioxidant stobadine ((-)-cis-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole) on the changes induced by the8-month hyperglycemia were studied. Hyperglycemia was induced by streptozotocin (STZ, 55 mg/kg i.v.). In the functional study, responses to KCl, acetylcholine (ACh), noradrenaline (NA) and hydrogen peroxide were evaluated under isometric conditions. The first changes in aortic reactivity started after I month of hyperglycemia and were exhibited by significantly increased NA-induced contractions. Relaxant responses to acetylcholine were decreased, although not significantly. Prolongation of hyperglycemia to 4, 6 and 8 months did not cause any additional significant changes in responsiveness toNA. Decreased ACh-induced relaxation and increased contractile responses to H2O2 were observed in month 4. The functional responses were not substantially deteriorated by prolongation of hyperglycemia to 6 and 8 months. Ultrastructural examination of the diabetic aorta showed disturbances in normaltissue organization. An 8-month supplementation of stobadine in diabetic rats resulted in the protection of aortic function as well as its ultrastructure. These results suggest that abnormalities occurring in the aorta of diabetic rats might result from the damaging effects of oxygen free radicals. (C) 2001 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:36:29