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Titolo:
Relationship between severity of essential hypertension and hyperuricemia
Autore:
Campo, C; Puig, JG; Segura, J; Alcazar, JM; Garcia-Robles, R; Ruilope, LM;
Indirizzi:
Hosp 12 Octubre, Unidad Hipertens, Dept Bioquim, E-28041 Madrid, Spain Hosp 12 Octubre Madrid Spain E-28041 Dept Bioquim, E-28041 Madrid, Spain Hosp La Paz, Med Interna Serv, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Med Interna Serv, Madrid, Spain Hosp Ramon y Cajal, Serv Endocrinol, E-28034 Madrid, Spain Hosp Ramon y Cajal Madrid Spain E-28034 ndocrinol, E-28034 Madrid, Spain
Titolo Testata:
MEDICINA CLINICA
fascicolo: 3, volume: 117, anno: 2001,
pagine: 85 - 89
SICI:
0025-7753(20010623)117:3<85:RBSOEH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
SPA
Soggetto:
SERUM URIC-ACID; CORONARY HEART-DISEASE; CARDIOVASCULAR-DISEASE; RISK FACTOR; FOLLOW-UP; INSULIN-RESISTANCE; BLOOD-PRESSURE; MORTALITY; PROGRAM; EVENTS;
Keywords:
serum uric acid; hyperuricemia; essential hipertension; target organ damage; renal function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Campo, C Hosp 12 Octubre, Unidad Hipertens, Dept Bioquim, Avda Cordoba S-N, E-28041Madrid, Spain Hosp 12 Octubre Avda Cordoba S-N Madrid Spain E-28041 rid, Spain
Citazione:
C. Campo et al., "Relationship between severity of essential hypertension and hyperuricemia", MED CLIN, 117(3), 2001, pp. 85-89

Abstract

BACKGROUND: Hyperuricemia has been associated with an increased risk of cardiovascular disease in hypertensive patients. However, the relation between serum orate and severity of hypertension has not been conclusively defined as yet. We aimed at finding out whether there exists an independent relationship between changes in the prevalence of hyperuricemia and severity of hypertension. PATIENTS AND METHOD: We studied 3 cohorts of patients aged 35 to 60 years with essential hypertension la diagnosed at a university hospital in Madrid, Spain. The first cohort (before 1981) included 325 patients, the second (from 1981 to 1989) comprised 271 patients and the third cohort (from 1990 to 1999) included 545 patients. Disease severity ranged from 1 to 6 according to blood pressure levels at diagnosis (WHO/ISH grades 1, 2 or 3 were assigned 1, 2 or 3 points, respectively) and target organ damage (left ventricular hypertrophy, hypertensive retinal vascular changes, and proteinuria above 3 mg/day; one point each). RESULTS: Mean serum urate concentrations in the 3 cohorts were 6.6, 5.8 and 5.5 mg/dL, respectively. (p < 0.05 for all comparisons). 39% of patients in the first cohort had a serum orate concentration > 7.0 mg/dL whereas only 18.1% patients in the third group showed hyperuricemia (difference: 20.9%; 95% CI, 10.1 to 32.3; p < 0.05). Severity of hypertension was higher in the first cohort (mean <plus/minus> SD 2.50 +/- 1.31 points) than in the third group (1.96 +/- 1.06 points; p < 0.05), with the second cohort showing an intermediate severity (2.23 <plus/minus> 1.01 points). Serum orate levelswere directly related to the severity of hypertension in the 3 groups (r =0.08, p < 0.05). In a multivariate analysis, after adjustment for confounding variables, serum gyrate had no significant association with severity ofhypertension. However, target organ damage, systolic blood pressure and serum creatinine were all independent predictors of severity. CONCLUSIONS: Favourable changes in the severity of hypertension for a timeperiod significantly correlate with decreases in hyperuricemia prevalence in the same period. On the other hand, hyperuricemia appears to be an indirect marker of hypertensive renal damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:08:10