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Titolo:
Interferons: potential roles in affect
Autore:
Hurlock, EC;
Indirizzi:
Columbia Univ, New York, NY USA Columbia Univ New York NY USAColumbia Univ, New York, NY USA
Titolo Testata:
MEDICAL HYPOTHESES
fascicolo: 5, volume: 56, anno: 2001,
pagine: 558 - 566
SICI:
0306-9877(200105)56:5<558:IPRIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; SEROTONIN 5-HT2C RECEPTOR; CENTRAL-NERVOUS-SYSTEM; PRE-MESSENGER-RNA; ALPHA-INTERFERON; IFN-GAMMA; SCHIZOPHRENIC-PATIENTS; PREFRONTAL CORTEX; SIGNAL-TRANSDUCTION; PHOSPHOLIPASE A(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Hurlock, EC Anesthesiol P&S, Box 46,630 W 168th St, New York, NY USA Anesthesiol P&S Box 46,630 W 168th St New York NY USA NY USA
Citazione:
E.C. Hurlock, "Interferons: potential roles in affect", MED HYPOTH, 56(5), 2001, pp. 558-566

Abstract

A review of the literature on interferons was conducted and possible rolesin neuropsychiatric disorders with affective disturbances are assessed. Interferons and interferon receptors are present in the limbic system where they appear to exert physiological effects pertinent to affect, most potently when levels rise during CNS infections. Interferons interact closely withcytokines and nitric oxide, signaling molecules implicated in depression. Results from knock-out mice suggest a role for interferon-gamma in moderating fear and anxiety, while other lines of evidence point to a role in arousal and circadian rhythms. The interferon-alpha receptor deploys an argininemethyltransferase affecting RNA editing and splicing, which seem to be disrupted in schizophrenia and bipolar disorder. S-Adenosylmethionine (SAMe), an effective antidepressant, may owe its effects in the latter disorders inpart to variations in the strength of interferon-alpha signaling impactingRNA processing. Antiviral effects of interferons are of interest in lieu of viral theories of affective disorders. Finally, the relative levels of interferons gamma and alpha might play important roles in neural, and glial, development, as well as the dialog between the CNS and the immune system. (C) 2001 Harcourt Publishers Ltd.

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Documento generato il 10/12/19 alle ore 01:17:16