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Titolo:
Specific expression of the retinoic acid-synthesizing enzyme RALDH2 duringmouse inner ear development
Autore:
Romand, R; Albuisson, E; Niederreither, K; Fraulob, V; Chambon, P; Dolle, P;
Indirizzi:
Univ Clermont Ferrand, Lab Neurobiol, F-63177 Aubiere, France Univ Clermont Ferrand Aubiere France F-63177 ol, F-63177 Aubiere, France Univ Auvergne, Fac Med, Lab Informat Med, F-63000 Clermont Ferrand, FranceUniv Auvergne Clermont Ferrand France F-63000 0 Clermont Ferrand, France Coll France, CNRS, INSERM, Inst Genet & Biol Mol & Cell,ULP, F-67404 Strasbourg, France Coll France Strasbourg France F-67404 ll,ULP, F-67404 Strasbourg, France
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 106, anno: 2001,
pagine: 185 - 189
SICI:
0925-4773(200108)106:1-2<185:SEOTRA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINALDEHYDE DEHYDROGENASE; VENTRAL RETINA; OTIC VESICLE; PAX2; GENE; EMBRYO; SYSTEM; ORGAN; CORTI;
Keywords:
cochlea; in situ hybridization; NKx5.1; otocyst; Pax2; Reissner membrane; retinaldehyde dehydrogenase; Trp-2; retinoids; stria vascularis; vestibule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Romand, R Univ Clermont Ferrand, Lab Neurobiol, F-63177 Aubiere, France Univ Clermont Ferrand Aubiere France F-63177 7 Aubiere, France
Citazione:
R. Romand et al., "Specific expression of the retinoic acid-synthesizing enzyme RALDH2 duringmouse inner ear development", MECH DEVEL, 106(1-2), 2001, pp. 185-189

Abstract

Retinoid binding proteins and nuclear receptors are expressed in the developing mouse inner car. Here. we report that the retinaldehyde dehydrogenase2 (Raldh2) gene, whose product is involved in the enzymatic generation of retinoic acid (RA), exhibits a restricted expression pattern during mouse inner ear ontogenesis. The Raldh2 gene is first expressed at embryonic day (E) 10.5 in a V-shaped medio-dorsal region of the otocyst outer epithelium. which evolves as two separate domains upon otocyst morphogenesis. At E14.5,Raldh2 is expressed in two areas of the utricle epithelium and specific regions of the saccule and cochlear mesenchyme. Later, Raldh2 transcripts arerestricted to two cochlear areas, the stria vascularis and Reissner membrane. Raldh2 mesenchymal expression did not correlate with migrating neural crest-derived melanoblasts. These restricted expression domains may correspond to specific sites of RA synthesis during inner ear morphogenesis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:02:02