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Titolo:
A possible meiotic function of the peculiar patterns of gene expression inmammalian spermatogenic cells
Autore:
Kleene, KC;
Indirizzi:
Univ Massachusetts, Dept Biol, Boston, MA 02125 USA Univ Massachusetts Boston MA USA 02125 s, Dept Biol, Boston, MA 02125 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 106, anno: 2001,
pagine: 3 - 23
SICI:
0925-4773(200108)106:1-2<3:APMFOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLY(A) BINDING-PROTEIN; MALE GERM-CELLS; HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; MITOCHONDRIAL CAPSULE SELENOPROTEIN; TRANSCRIPTION INITIATION SITES; ANGIOTENSIN-CONVERTING ENZYME; TESTIS-SPECIFIC TRANSCRIPTION; MESSENGER-RIBONUCLEIC-ACID; Y-BOX PROTEIN; TISSUE-SPECIFIC EXPRESSION;
Keywords:
spermatogenesis; translational regulation; transcriptional promiscuity; meiosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
242
Recensione:
Indirizzi per estratti:
Indirizzo: Kleene, KC Univ Massachusetts, Dept Biol, Boston, MA 02125 USA Univ Massachusetts Boston MA USA 02125 l, Boston, MA 02125 USA
Citazione:
K.C. Kleene, "A possible meiotic function of the peculiar patterns of gene expression inmammalian spermatogenic cells", MECH DEVEL, 106(1-2), 2001, pp. 3-23

Abstract

This review focuses on the striking differences in the patterns of transcription and translation in somatic and spermatogenic cells in mammals. In early haploid cells, mRNA translation evidently functions to restrict the synthesis of certain proteins, notably protamines, to transcriptionally inert late haploid cells. However, this does not explain why a substantial proportion of virtually all mRNA species are sequestered in translationally inactive free-messenger ribonucleoprotein particles (free-mRNPs) in meiotic cells, since most mRNAs undergo little or no increase in translational activityin transcriptionally active early haploid cells. In addition, most mRNAs in meiotic cells appear to be overexpressed because they are never fully loaded on polysomes and the levels of the corresponding protein are often muchlower than the mRNA and are sometimes undetectable. A large number of genes are expressed at grossly higher levels in meiotic and/or early haploid spermatogenic cells than in somatic cells, yet they too are translated inefficiently. Many genes utilize alternative promoters in somatic and spermatogenic cells. Some of the resulting spermatogenic cell-altered transcripts (SCATs) encode proteins with novel functions, while others contain features intheir 5 ' -UTRs, secondary structure or upstream reading frames, that are predicted to inhibit translation. This review proposes that the transcriptional machinery is modified to provide access to specific DNA sequences during meiosis, which leads to mRNA overexpression and creates a need for translational fine-tuning to prevent deleterious consequences of overproducing proteins. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:19:10