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Titolo:
Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM)
Autore:
Beksac, M; Ma, M; Akyerli, C; DerDanielian, M; Zhang, L; Liu, J; Arat, M; Konuk, N; Koc, H; Ozcelik, T; Vescio, R; Berenson, JR;
Indirizzi:
Ankara Univ, Sch Med, Ibni Sina Hosp, Dept Hematol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 Dept Hematol, TR-06100 Ankara, Turkey Bilkent Univ, Dept Mol Biol & Genet, Ankara, Turkey Bilkent Univ Ankara Turkey Univ, Dept Mol Biol & Genet, Ankara, Turkey Univ Calif Los Angeles, Sch Med, Cedars Sinai Med Ctr, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
LEUKEMIA
fascicolo: 8, volume: 15, anno: 2001,
pagine: 1268 - 1273
SICI:
0887-6924(200108)15:8<1268:FDOHH8>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; BLOOD DENDRITIC CELLS; KAPOSIS-SARCOMA; DNA-SEQUENCES; HUMAN-HERPESVIRUS-8; INFECTION; KSHV/HHV-8; LYMPHOMA;
Keywords:
HHV-8; multiple myeloma; frequency and sequence; Turkish patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Beksac, M Ankara Univ, Sch Med, Ibni Sina Hosp, Dept Hematol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 ol, TR-06100 Ankara, Turkey
Citazione:
M. Beksac et al., "Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM)", LEUKEMIA, 15(8), 2001, pp. 1268-1273

Abstract

In order to investigate the frequency of HHV-8 in MM patients from anothergeographic location, we obtained fresh bone marrow (BM) biopsies from Turkish patients with MM (n = 21), monoclonal gammopathy of undetermined significance (MGUS) (n = 2), plasmacytoma (n = 1) with BM plasma cell infiltration, various hematological disorders (n = 6), and five healthy Turkish controls. The frequency of HHV-8 was analyzed by polymerase chain reaction (PCR) in two independent laboratories in the USA and in Turkey. Using fresh BM biopsies, 17/21 MINI patients were positive for HHV-8 whereas all five healthy controls, and six patients with other hematological disorders were negative. Two patients with MGUS, and one patient with a solitary plasmacytoma were also negative. The data from the two laboratories were completely concordant. Also using primer pairs for v IRF and v IL-8R confirmed the results observed with the KS330(233) primers. Furthermore, sequence analysis demonstrated a C3 strain pattern in the ORF26 region which was also found in MM patients from the US. Thus, HHV-8 is present in the majority of Turkish NIM patients, and the absence of the virus in healthy controls further supports its role in the pathogenesis of MM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:08:46