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Titolo:
DECREASED CELLULAR MG2- CELL MODELS FOR THE PATHOGENESIS OF PRIMARY HYPERTENSION( CONCENTRATIONS IN A SUBGROUP OF HYPERTENSIVES )
Autore:
KISTERS K; TEPEL M; SPIEKER C; DIETL KH; BARENBROCK M; RAHN KH; ZIDEK W;
Indirizzi:
UNIV MUNSTER,MED POLICLIN,ALBERT SCHWEITZER STR 33 D-48149 MUNSTER GERMANY
Titolo Testata:
Journal of human hypertension
fascicolo: 6, volume: 11, anno: 1997,
pagine: 367 - 372
SICI:
0950-9240(1997)11:6<367:DCMCMF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR FREE-MAGNESIUM; VASCULAR SMOOTH-MUSCLE; CYTOSOLIC FREE CALCIUM; BLOOD-PRESSURE; RAT; PREECLAMPSIA; ERYTHROCYTES; DEFICIENCY; PLATELETS; PLASMA;
Keywords:
CELLULAR MG2+; LYMPHOCYTES; THROMBOCYTES; MAG-FURA-II; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
K. Kisters et al., "DECREASED CELLULAR MG2- CELL MODELS FOR THE PATHOGENESIS OF PRIMARY HYPERTENSION( CONCENTRATIONS IN A SUBGROUP OF HYPERTENSIVES )", Journal of human hypertension, 11(6), 1997, pp. 367-372

Abstract

A new method to determine total Mg2+ content in lymphocytes was developed, offering advantages for routine measurements as compared to fluorescence methods. Intracellular Mg2+ measurements were performed in lymphocytes of 18 untreated normotensive and 19 untreated essential hypertensive patients. Mg2+ content was referred to lymphocytic protein, which was determined according to Bradford's method. Mg2+ measurements were performed by atomic absorption spectroscopy using a Video 12 apparatus from Thermo Electron Instrumentation Laboratory, Andover, MA, USA. The results show that in patients with essential hypertension, total intralymphocytic Mg2+ content is significantly lower (0.07 +/- 0.05 mmol/g lymphocytic protein, mean +/- s.d.) as compared to controls (0.11 +/- 0.04 mmol/g lymphocytic protein, mean +/- s.d., P < 0.05). Freeintracellular Mg2+ content was measured in lymphocytes by the fluorescent indicator mag-fura-II, showing no significant difference in normotensives and hypertensives (0.30 +/- 0.16 vs 0.38 +/- 0.17 mmol/l). Inplatelets free intracellular Mg2+ concentrations were not found of significant difference in normotensive and hypertensive patients (0.52 +/- 0.23 vs 0.47 +/- 0.27 mmol/l) using mag-fura-II, In plasma Mg2+ concentrations there was no significant difference in the normotensive and hypertensive group (0.92 +/- 0.07 vs 0.88 to 0.07 mmol/l). There wasno correlation between plasma, free or total cellular magnesium concentrations in each group. Furthermore this method also seems suitable for routine measurements of total intracellular Mg2+ concentrations in even larger groups of patients in comparison with fluorescent indicator measurements like mag-fura-II, Lowered total intracellular Mg2+ concentrations in a subgroup of primary hypertension may contribute to thedevelopment of this disorder, perhaps due to different buffering systems.

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Documento generato il 30/03/20 alle ore 00:06:01